Cat. No.: HY-N10521

6'-Sialyllactose

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

6'-Sialyllactose promotes the growth of beneficial bacteria (such as Bifidobacterium and lactobacillus) and inhibits the proliferation of harmful bacteria. 6'-Sialyllactose exhibits anti-inflammatory and anti-angiogenic activities. 6'-Sialyllactose promotes the muscle health.

For research use only. We do not sell to patients.

Purity: 99.60%
CAS No.: 35890-39-2
Formula: C₂₃H₃₉NO₁₉
Molecular Weight:633.55

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

6'-Sialyllactose Chemical Structure

CAS No.: 35890-39-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All VEGFR Isoforms :

All Akt Isoforms :

All ERK Isoforms :

In Vitro

6'-Sialyllactose (0-50 μM, 24 h) inhibits Dihydrotestosterone-induced proliferation of HUVECs, suppresses tubular structure formation, inhibits the activation of VEGFR-2-related Akt-ERK signaling pathway^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[4]

Cell Line:

HUVEC
Concentration:

0-50 μM
Incubation Time:

24 h
Result:

Downregulated levels of p-Akt and p-ERK.

In Vivo

6'-Sialyllactose (5% added to mouse diet, 2 weeks) alleviates the anxiety-like behavior of mice, regulates the flora composition in social disruption (SDR)-stressed mouse model^[2].
6'-Sialyllactose (100 mg/kg, po, once daily, 5 times a week for 12 weeks) increases the muscle mass and strength, thereby improving the exercise endurance of mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SDR-stressed mouse model^[2]
Dosage:

5% added to mouse diet
Administration:

po, 2 weeks
Result:

Reduced the anxiety-like behavior in open field tests.
Maintained the number of DCX-positive cells in the hippocampus.

Animal Model:

C57BL/6J mouse models^[3]
Dosage:

100 mg/kg
Administration:

po, once daily, 5 times a week for 12 weeks
Result:

Increased the mouse running distance.
Increased the absolute weight of gastrocnemius and soleus muscles.

Chemical Information

CAS No. 35890-39-2
Appearance Solid
Molecular Weight 633.55
Formula C₂₃H₃₉NO₁₉
Color White to off-white
SMILES

O=C[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]([C@@H]([C@H]([C@H]1O)O)O)O[C@@H]1CO[C@]2(O[C@@]([C@@H]([C@H](C2)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)C(O)=O
Structure Classification
- Saccharides
- Polysaccharides
Initial Source
- Endogenous metabolite
Clostridium perfringens
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

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Journal Impact Factor

Future Sci OA

The potential of human milk oligosaccharides in ameliorating traumatic brain injury-induced cognitive impairment in mice. [Abstract]

2026 Dec;12(1):2622241. PMID: 41622772

Solvent & Solubility

In Vitro:

H₂O : ≥ 50 mg/mL (78.92 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5784 mL

7.8920 mL

15.7841 mL

5 mM

0.3157 mL

1.5784 mL

3.1568 mL

10 mM

0.1578 mL

0.7892 mL

1.5784 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. MariarosariaMarotta, et al. The predominant milk oligosaccharide 6′-sialyllactose reduces the internalisation of Pseudomonas aeruginosa in human pneumocytes. Journal of Functional Foods Volume 6, January 2014, Pages 367-373.

[2]. Tarr AJ, et al., The prebiotics 3'Sialyllactose and 6'Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut-brain axis. Brain Behav Immun. 2015 Nov;50:166-177. [Content Brief]

[3]. Park EJ, et al., 6'-Sialyllactose Enhances Exercise Performance via Increased Muscle Mass and Strength. Nutrients. 2024 Aug 7;16(16):2600. [Content Brief]

[4]. Kim EY, et al., 6-sialyllactose ameliorates dihydrotestosterone-induced benign prostatic hyperplasia through suppressing VEGF-mediated angiogenesis. BMB Rep. 2019 Sep;52(9):560-565. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.5784 mL	7.8920 mL	15.7841 mL	39.4602 mL
	5 mM	0.3157 mL	1.5784 mL	3.1568 mL	7.8920 mL
	10 mM	0.1578 mL	0.7892 mL	1.5784 mL	3.9460 mL
	15 mM	0.1052 mL	0.5261 mL	1.0523 mL	2.6307 mL
	20 mM	0.0789 mL	0.3946 mL	0.7892 mL	1.9730 mL
	25 mM	0.0631 mL	0.3157 mL	0.6314 mL	1.5784 mL
	30 mM	0.0526 mL	0.2631 mL	0.5261 mL	1.3153 mL
	40 mM	0.0395 mL	0.1973 mL	0.3946 mL	0.9865 mL
	50 mM	0.0316 mL	0.1578 mL	0.3157 mL	0.7892 mL
	60 mM	0.0263 mL	0.1315 mL	0.2631 mL	0.6577 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

6'-Sialyllactose

1 Cited Publications

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6'-Sialyllactose

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Publications Citing Use of MedChemExpress (MCE) 6'-Sialyllactose

All VEGFR Isoforms

All Akt Isoforms

All ERK Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

6'-Sialyllactose Related Classifications

HY-N10521 Related Classifications