I-BET432
I-BET432 is a BET inhibitor. I-BET432 inhibits BRD4 N-terminal bromodomain (BD1) and the C-terminal bromodomain (BD2) with pIC50 values of 7.5 and 7.2, respectively. I-BET432 can be used as an oral candidate quality molecule for the research of multiple oncology and inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 3035187-74-4
- Formula: C18H21N3O3
- Molecular Weight:327.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
I-BET432 inhibits BRD4 BD1 and BD2 with pIC50 values of 7.5 and 7.2, respectively[1]. I-BET432 inhibits human whole blood MCP-1 with an pIC50 value of 7.4[1]. I-BET432 inhibits hERG with an pIC50 value ＜4.3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Rats PO/IV 3/1 mg/kg |
Dogs PO/IV 1.5/0.5 mg/kg |
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| CLb (mL/min/kg) | 26 | 28 |
| CLb,u (mL/min/kg) | 38 | 20 |
| Vss (L/kg) | 1.3 | 2.7 |
| Vss,u (L/kg) | 1.9 | 5.7 |
| t1/2 (h) | 0.74 | 1.4 |
| Fpo (%) | 67 | 79 |
| fub | 0.68 | 0.47 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3035187-74-4
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Molecular Weight 327.38
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Formula C18H21N3O3
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SMILES
O=C1N(C)C=C(C2=CN(C)N=C2)C3=CC([C@@H](O)CO)=CC=C3[C@H]1C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
I-BET432 Related Classifications
HY-151894 Related Classifications
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