3035187-74-4
3035187-74-4
Chemical Structure
I-BET432
- CAS No.: 3035187-74-4
- Formula:C18H21N3O3
- Molecular Weight:327.38
IUPAC Name: (1S,2Z,6Z,10R)-3,7,11,11-tetramethylbicyclo[8.1.0]undeca-2,6-diene
InChIKey: CJVJSGBELMMESS-DIFFPNOSSA-N
SMILES: O=C1N(C)C=C(C2=CN(C)N=C2)C3=CC([C@@H](O)CO)=CC=C3[C@H]1C
Biological Activity: I-BET432 is a BET inhibitor. I-BET432 inhibits BRD4 N-terminal bromodomain (BD1) and the C-terminal bromodomain (BD2) with pIC50 values of 7.5 and 7.2, respectively. I-BET432 can be used as an oral candidate quality molecule for the research of multiple oncology and inflammatory diseases[1].
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I-BET432 | I-BET432 is a BET inhibitor. I-BET432 inhibits BRD4 N-terminal bromodomain (BD1) and the C-terminal bromodomain (BD2) with pIC50 values of 7.5 and 7.2, respectively. I-BET432 can be used as an oral candidate quality molecule for the research of multiple oncology and inflammatory diseases. | |||||||||||||||||||||
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References
Keywords
