GPR68
G Protein-Coupled Receptor 68
GPR68 was first cloned from the HEY human ovarian cancer cell line and named ovarian cancer G protein-coupled receptor 1 (OGR1). GPR68 is a proton-sensing G-protein-coupled receptor (GPCR) that responds to extracellular acidity and regulates a variety of cellular functions. GPR68 mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca 2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8.
All Product Categories
-
GPR68 Related Products (6)
-
Ogremorphin
0 ImagesSynonyms: OGM; GPR68-IN-1; OGM-8345Ogremorphin (OGM) is a G protein coupled sensor GPR68 inhibitor with anti-inflammatory and anti-tumor activities. Ogremorphin can inhibit the migration of human melanoma cells and induce ferroptosis in glioblastoma cells. -
loading...loading...
-
-
Ogerin
0 ImagesOgerin, a chemical probe, is a selective GPR68 positive aliasing modulator (PAM) (pEC50=6.83) with a moderate antagonistic effect on A2A (Ki=220 nM). Ogerin inhibits the fear conditioning reflex in mice and also inhibits TGF-β-induced myofibroblast differentiation of fibroblasts from multiple organ systems. Ogerin can be used in the studies of fibrotic diseases and neurological disorders. -
loading...loading...
-
- Sulazepam-d5
-
loading...loading...
-
- Ogerin analogue 1
-
loading...loading...
-
-
GPR68 antagonist 1
0 ImagesCat. No.: HY-181485GPR68 antagonist 1 is a GPR68 antagonist with an IC50 of 81 nM. GPR68 antagonist 1 inhibits the mouse GPR68-mediated cAMP signaling pathway with an IC50 of 179 nM. GPR68 antagonist 1 alleviates disease symptoms in a dextran sulfate sodium (DSS) (HY-116282C)-induced mouse model of inflammatory bowel disease. GPR68 antagonist 1 is applicable to research related to inflammatory bowel disease. -
loading...loading...
-
