1309198-71-7
Chemical Structure
Ogerin
- CAS No.: 1309198-71-7
- Formula:C17H17N5O
- Molecular Weight:307.35
IUPAC Name: (2-(4-amino-6-(benzylamino)-1,3,5-triazin-2-yl)phenyl)methanol
InChIKey: MDGIEDNDSFMSLP-UHFFFAOYSA-N
SMILES: OCC1=C(C2=NC(N)=NC(NCC3=CC=CC=C3)=N2)C=CC=C1
Biological Activity: Ogerin, a chemical probe, is a selective GPR68 positive aliasing modulator (PAM) (pEC50=6.83) with a moderate antagonistic effect on A2A (Ki=220 nM). Ogerin inhibits the fear conditioning reflex in mice and also inhibits TGF-β-induced myofibroblast differentiation of fibroblasts from multiple organ systems. Ogerin can be used in the studies of fibrotic diseases and neurological disorders[1][2].
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Ogerin | 99.94% | Ogerin, a chemical probe, is a selective GPR68 positive aliasing modulator (PAM) (pEC50=6.83) with a moderate antagonistic effect on A2A (Ki=220 nM). Ogerin inhibits the fear conditioning reflex in mice and also inhibits TGF-β-induced myofibroblast differentiation of fibroblasts from multiple organ systems. Ogerin can be used in the studies of fibrotic diseases and neurological disorders. | ||||||||||||||||||||
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Ogerin (Standard) | ≥98% | Ogerin (Standard) is the analytical standard of Ogerin (HY-110279). This product is intended for research and analytical applications. Ogerin, a chemical probe, is a selective GPR68 positive aliasing modulator (PAM) (pEC50=6.83) with a moderate antagonistic effect on A2A (Ki=220 nM). Ogerin inhibits the fear conditioning reflex in mice and also inhibits TGF-β-induced myofibroblast differentiation of fibroblasts from multiple organ systems. Ogerin can be used in the studies of fibrotic diseases and neurological disorders. | ||||||||||||||||||||
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References
- [1]. Bell TJ, et al. Ogerin mediated inhibition of TGF-β(1) induced myofibroblast differentiation is potentiated by acidic pH. PLoS One. 2022 Jul 28;17(7):e0271608. [Content Brief]
- [2]. Huang XP, et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26;527(7579):477-83. [Content Brief]
