1. Apoptosis
  2. Apoptosis
  3. Sophoraflavanone G

Sophoraflavanone G (Synonyms: Kushenol F)

Cat. No.: HY-N1231
Handling Instructions

Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.  Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.

For research use only. We do not sell to patients.

Sophoraflavanone G Chemical Structure

Sophoraflavanone G Chemical Structure

CAS No. : 97938-30-2

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Description

Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.  Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways[1][2].

IC50 & Target

IC50: 29.7 μM (MDA-MB-231 cell)[1]

In Vitro

Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells in a dose-dependent manner[1].
Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated "intrinsic" pathway[1]
Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC50 value of 29.7 ± 5.2 μM[2]<.br>

Molecular Weight

424.49

Formula

C₂₅H₂₈O₆

CAS No.

97938-30-2

SMILES

O=C1C[[email protected]@H](C2=CC=C(O)C=C2O)OC3=C(C[[email protected]](C(C)=C)C/C=C(C)\C)C(O)=CC(O)=C13

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Sophoraflavanone GKushenol FApoptosisMDA-MB-231HL60apoptosisanti-infammatoryInhibitorinhibitorinhibit

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