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SPR inhibitor 3 (Synonyms: SPRi3)

Cat. No.: HY-115510 Purity: 99.91%
Handling Instructions

SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels.

For research use only. We do not sell to patients.

SPR inhibitor 3 Chemical Structure

SPR inhibitor 3 Chemical Structure

CAS No. : 1292285-54-1

Size Price Stock Quantity
5 mg USD 130 In-stock
Estimated Time of Arrival: December 31
10 mg USD 185 In-stock
Estimated Time of Arrival: December 31
50 mg USD 630 In-stock
Estimated Time of Arrival: December 31
100 mg USD 680 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels[1][2][3].

IC50 & Target

IC50: 74 nM (sepiapterin reductase)[1]

In Vitro

SPR inhibitor 3 (SPRi3) also significantly reduces SPR activity in mouse primary cultures of sensory neurons (IC50=0.45 μM) without affecting the activity of GTP cyclohydroxylase 1 enzyme (GCH1)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

262.30

Formula

C₁₄H₁₈N₂O₃

CAS No.

1292285-54-1

SMILES

O=C(NCCC1=C(C)NC2=C1C=C(O)C=C2)COC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (476.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8124 mL 19.0621 mL 38.1243 mL
5 mM 0.7625 mL 3.8124 mL 7.6249 mL
10 mM 0.3812 mL 1.9062 mL 3.8124 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (23.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (23.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (23.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SPR inhibitor 3SPRi3SPR inhibitor3SPR inhibitor-3SPRi 3SPRi-3OthersInhibitorinhibitorinhibit

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Product Name:
SPR inhibitor 3
Cat. No.:
HY-115510
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