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SPR inhibitor 3 (Synonyms: SPRi3)

Cat. No.: HY-115510
Handling Instructions

SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels.

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SPR inhibitor 3 Chemical Structure

SPR inhibitor 3 Chemical Structure

CAS No. : 1292285-54-1

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Description

SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels[1][2][3].

IC50 & Target

IC50: 74 nM (sepiapterin reductase)[1]

In Vitro

SPR inhibitor 3 (SPRi3) also significantly reduces SPR activity in mouse primary cultures of sensory neurons (IC50=0.45 μM) without affecting the activity of GTP cyclohydroxylase 1 enzyme (GCH1)[1].

Molecular Weight

262.30

Formula

C₁₄H₁₈N₂O₃

CAS No.

1292285-54-1

SMILES

O=C(NCCC1=C(C)NC2=C1C=C(O)C=C2)COC

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SPR inhibitor 3SPRi3SPR inhibitor3SPR inhibitor-3SPRi 3SPRi-3OthersInhibitorinhibitorinhibit

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SPR inhibitor 3
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