2. Anti-infection Apoptosis
  3. Bacterial TNF Receptor
  4. Anti-inflammatory agent 11

Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research.

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Anti-inflammatory agent 11 Chemical Structure

Anti-inflammatory agent 11 Chemical Structure

CAS No. : 63932-07-0

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Anti-inflammatory agent 11 Related Antibodies

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Description

Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research[1].

IC50 & Target

MIC50: 1.3 ± 1.1 μM (Mtb H37Rv), 6.9 ± 0.8 μM (Mtb M299); IC50: 7.4 ± 1.1 μM (NO)[1]
In Vitro

Anti-inflammatory agent 11 (compound 16) is active in the reduction of accumulated nitrite, with an IC50 of 64.8 ± 1.0 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 11 Related Antibodies
Molecular Weight

286.35

Formula

C14H14N4OS
CAS No.
SMILES

[H]N(C(N(NC(C1=CC=NC=C1)=O)[H])=S)CC2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 1163932-07-0BacterialTNF ReceptorTumor Necrosis Factor ReceptorTNFRthiourea derivativeantimycobacterialanti-inflammatorylow cytotoxicityTuberculosisTBMtb H37RvMtb M299MycobacteriumbacterialInhibitorinhibitorinhibit

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