63932-07-0
Chemical Structure
Anti-inflammatory agent 11
- CAS No.: 63932-07-0
- Formula:C14H14N4OS
- Molecular Weight:286.35
IUPAC Name: N-benzyl-2-isonicotinoylhydrazine-1-carbothioamide
InChIKey: XFSPROBIMFEXRO-UHFFFAOYSA-N
SMILES: [H]N(C(N(NC(C1=CC=NC=C1)=O)[H])=S)CC2=CC=CC=C2
Biological Activity: Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research[1].
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Anti-inflammatory agent 11 | Anti-inflammatory agent 11 (compound 16) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 11 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 1.3 and 6.9 μM, respectively. Anti-inflammatory agent 11 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 11 can be used for tuberculosis (TB) research. | |||||||||||||||||||||
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