2. Anti-infection
  3. Bacterial
  4. Antimicrobial agent-7

Antimicrobial agent-7 (Compound 12) is a potent antimicrobial agent, and shows potent antimicrobial activity with an MIC range of 2-8 μg/mL against Gram-negative and Gram-positive bacteria. Antimicrobial agent-7 shows anti-inflammatory activity against lipopolysaccharide-induced inflammation.

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Antimicrobial agent-7 Chemical Structure

Antimicrobial agent-7 Chemical Structure

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Antimicrobial agent-7 Related Antibodies

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Description

Antimicrobial agent-7 (Compound 12) is a potent antimicrobial agent, and shows potent antimicrobial activity with an MIC range of 2-8 μg/mL against Gram-negative and Gram-positive bacteria. Antimicrobial agent-7 shows anti-inflammatory activity against lipopolysaccharide-induced inflammation[1].

In Vitro

Antimicrobial agent-7 (2.8-56.4 μM; 24 h) inhibits Gram-negative bacteria and Gram-positive bacteria growth[1].
Antimicrobial agent-7 (5 and 20 μg/mL; 18 h) inhibits the production of nitric oxide (NO) and tumor necrosis factor-α (TNF-α) by lipopolysaccharide-stimulated in RAW 264.7 cells[1].
Antimicrobial agent-7 exhibits proteolytic resistance and salt/serum stability[1].
Antimicrobial agent-7 displays synergistic or additive effects when combined with selected clinically used antibiotics[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antimicrobial agent-7 Related Antibodies

Cell Viability Assay[1]

Cell Line: E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], S. epidermidis [KCTC 1917] and S. aureus [KCTC1621]
Concentration: 2.8-56.4 μM
Incubation Time: 24 hours
Result: Inhibited Gram-negative bacteria with MIC values of 17.7 and 4.8 μM for E. coli [KCTC 1682] and P. aeruginosa [KCTC 1637], respectively.
Inhibited Gram- positive bacteria with MIC values of 4.8 μM for S. epidermidis [KCTC 1917] and S. aureus [KCTC1621].

Cell Viability Assay[1]

Cell Line: RAW 264.7 macrophages
Concentration: 5 and 20 μg/mL
Incubation Time: 18 hours
Result: Observed LPS-stimulated production of NO with an inhibitory rate of 68.09% at 5 μg/mL.
Exhibited inhibitory effects on the LPS-stimulated production of TNF-α with an inhibitory rate of 99.83% at 20 μg/mL.
Molecular Weight

824.99

Formula

C36H56N24
SMILES

NC(NCCNC1=NC(NCCNC(N)=N)=NC(N(C(CN2C3=NC(NCCNC(N)=N)=NC(NCCNC(N)=N)=N3)CC4=CC=CC=C4)CC2CC5=CC=CC=C5)=N1)=N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antimicrobial agent-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimicrobial agent-7Antimicrobial agent7Antimicrobial agent 7Bacterialanti-inflammatory activityE. coli [KCTC 1682]P. aeruginosa [KCTC 1637]S. epidermidis [KCTC 1917] S. aureus [KCTC1621]Inhibitorinhibitorinhibit

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