2. Membrane Transporter/Ion Channel Apoptosis
  3. P2X Receptor Apoptosis
  4. Bullatine A

Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed.

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Bullatine A Chemical Structure

Bullatine A Chemical Structure

CAS No. : 1354-84-3

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Description

Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses[1]. Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed[2].

IC50 & Target

P2X7 Receptor

 

Molecular Weight

343.50

Formula

C22H33NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H](C1C2([C@@H]3O)C4C[C@]5([H])[C@@]6(C)CCCC51C4N(CC)C6)C(CC2)C3=C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (36.39 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9112 mL 14.5560 mL 29.1121 mL
5 mM 0.5822 mL 2.9112 mL 5.8224 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9112 mL 14.5560 mL 29.1121 mL 72.7802 mL
5 mM 0.5822 mL 2.9112 mL 5.8224 mL 14.5560 mL
10 mM 0.2911 mL 1.4556 mL 2.9112 mL 7.2780 mL
15 mM 0.1941 mL 0.9704 mL 1.9408 mL 4.8520 mL
20 mM 0.1456 mL 0.7278 mL 1.4556 mL 3.6390 mL
25 mM 0.1164 mL 0.5822 mL 1.1645 mL 2.9112 mL
30 mM 0.0970 mL 0.4852 mL 0.9704 mL 2.4260 mL
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Bullatine A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bullatine A1354-84-3P2X ReceptorApoptosisP2XRsInhibitorinhibitorinhibit

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