1354-84-3
Chemical Structure
Bullatine A
- CAS No.: 1354-84-3
- Formula:C22H33NO2
- Molecular Weight:343.50
IUPAC Name: (3R,7S,10R,13R)-1-ethyl-3-methyl-9-methylenedodecahydro-8H-3,6a,11-(epiethane[1,1,2]triyl)-8,10a-ethanoindeno[2,1-b]azocine-7,10-diol
InChIKey: OVXLNQAYPUEDSI-TZCFEFNFSA-N
SMILES: O[C@H](C1C2([C@@H]3O)C4C[C@]5([H])[C@@]6(C)CCCC51C4N(CC)C6)C(CC2)C3=C
Biological Activity: Bullatine A, a diterpenoid alkaloid, is a potent P2X7 antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting SIRT6. Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS (HY-D1056)-induced systemic inflammatory response by inhibiting the ROS/JNK/NF-κB pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress (CSDS) mice. Bullatine A can be used for the study of inflammation, glioblastoma (GBM) and depression[1][2][3][4][5].
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Bullatine A | 98.0% | Bullatine A, a diterpenoid alkaloid, is a potent P2X7 antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting SIRT6. Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS (HY-D1056)-induced systemic inflammatory response by inhibiting the ROS/JNK/NF-κB pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress (CSDS) mice. Bullatine A can be used for the study of inflammation, glioblastoma (GBM) and depression. | ||||||||||||||||||||
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- [1]. Li J, et al. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, could attenuate ATP-induced BV-2 microglia death/apoptosis via P2X receptor pathways. Brain Res Bull. 2013 Aug;97:81-5. [Content Brief]
- [2]. Huang Q, et al. Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models. J Neuroinflammation. 2016 Aug 30;13(1):214. [Content Brief]
- [3]. Liu S, et al. Bullatine A exerts anti-inflammatory effects by inhibiting the ROS/JNK/NF-κB pathway and attenuating systemic inflammatory responses in mice. Pharm Biol. 2022 Dec;60(1):1840-1849. [Content Brief]
- [4]. Wang Z, et al. Bullatine A suppresses glioma cell growth by targeting SIRT6. Heliyon. 2024 Dec 24;11(1):e41440. [Content Brief]
- [5]. Zhang JR, et al. Bullatine A has an antidepressant effect in chronic social defeat stress mice; Implication of microglial inflammasome. Brain Res Bull. 2023 Apr;195:130-140. [Content Brief]
Keywords
