Napelline
Napelline is an alkaloid extracted from Baikal aconite (Aconitum baikalensis). Napelline can be used for the research of inflammation, antiexudative and analgesic.
For research use only. We do not sell to patients.
- CAS No.: 5008-52-6
- Formula: C22H33NO3
- Molecular Weight:359.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Napelline (0.025 mg/kg; adjuvant injection) exhibits the highest analgesic activities[1].
Napelline preventive treatment provides significant antiexudative effect. Napelline can have greater influence on the initial stages of inflammation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 5008-52-6
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Molecular Weight 359.50
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Formula C22H33NO3
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SMILES
O[C@@H]1[C@@]23[C@@]4([H])[C@]5(C[C@H](C([C@H]5O)=C)[C@H](C4)O)[C@@H]6[C@@]2([H])N(C[C@@]([C@H]3C6)(CC1)C)CC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
References
[1]. Nesterova YV, et al. Analgesic activity of diterpene alkaloids from Aconitum baikalensis. Bull Exp Biol Med. 2014;157(4):488-491. [Content Brief]
[2]. Nesterova YV, et al. Anti-inflammatory activity of diterpene alkaloids from Aconitum baikalense. Bull Exp Biol Med. 2014;156(5):665-668. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Napelline Related Classifications
HY-N9537 Related Classifications
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