Analgesic activity of diterpene alkaloids from Aconitum baikalensis

  • Bull Exp Biol Med. 2014 Aug;157(4):488-91. doi: 10.1007/s10517-014-2598-6.
Yu V Nesterova  1 ,  T N Povet'yeva ,  N I Suslov ,  G N Zyuz'kov ,  S V Pushkarskii ,  S G Aksinenko ,  E E Schultz ,  S S Kravtsova ,  A V Krapivin
Affiliations
  • 1. E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, [email protected].
PMID: 25110090 DOI: 10.1007/s10517-014-2598-6
Abstract

We compared analgesic activities of individual Alkaloids extracted from Baikal aconite (Aconitum baikalensis): napelline, hypaconitine, songorine, mesaconitine, 12-epinapelline N-oxide. The detected analgesic activity was comparable to that of sodium metamizole. The mechanisms of analgesia were different in diterpene Alkaloids of different structure. The antinociceptive effect of atisine Alkaloids (12-epinapelline N-oxide, songorine) was naloxonedependent and realized via Opioid Receptor modulation.

Products