Anti-inflammatory activity of diterpene alkaloids from Aconitum baikalense

  • Bull Exp Biol Med. 2014 Mar;156(5):665-8. doi: 10.1007/s10517-014-2421-4.
Yu V Nesterova  1 ,  T N Povetieva ,  N I Suslov ,  G N Zyuz'kov ,  S G Aksinenko ,  S V Pushkarskii ,  A V Krapivin
Affiliations
  • 1. Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, [email protected].
PMID: 24770754 DOI: 10.1007/s10517-014-2421-4
Abstract

We compared anti-inflammatory activity of individual diterpene Alkaloids isolated from Aconitum baikalense (napelline, songorine, hypaconitine, mesaconitine, 12-epinapelline N-oxide) under conditions of acute inflammation of different genesis. The tested substances showed high antiexudative activity comparable with that of sodium diclofenac. Unlike nonsteroidal anti-inflammatory drugs, diterpene Alkaloids exerted no ulcerogenic effect.

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