2. Natural Products
  3. Plants
  4. Ranunculaceae
  5.  Aconitum carmichaeli Debx.

 Aconitum carmichaeli Debx.

 Aconitum carmichaeli Debx. (56):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0217
    Benzoylaconine 466-24-0 99.92%
    Benzoylaconine (Benzoylaconitine) is an orally active monoester alkaloid found in the traditional Chinese medicine Aconitum carmichaelii. Benzoylaconine is an ACE2 agonist (EC50: 1.5 μM) with antihypertensive and anti-heart failure effects. Benzoylaconine inhibits TLR-induced MAPK and NF-κB pathways to exert anti-inflammatory effects. Benzoylaconine upregulates the protein levels of P-gp, MRP2, and has anti-tumor effects.
    Benzoylaconine
  • HY-N2037
    Higenamine 5843-65-2 99.31%
    Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases.
    Higenamine
  • HY-N0218
    Benzoylmesaconine 63238-67-5 99.56%
    Benzoylmesaconine is a monoester-type alkaloid and is the most abundant component of Wutou decoction, which is widely used in China for rheumatoid arthritis. Benzoylmesaconine exhibits potent anti-inflammatory properties by inhibiting NF-κB. Benzoylmesaconine can suppress NLRP3 inflammasome activation by inhibiting IL-1β secretion and GSDMD-N protein expression. Benzoylmesaconine reduces intracellular K+ efflux and disrupts NLRP3 inflammasome assembly.
    Benzoylmesaconine
  • HY-N0267
    Hypaconitine 6900-87-4 99.49%
    Hypaconitine inhibits the KCNH2 current with an IC50 of 8.1 nM, and exhibits cardiotoxicity. Hypaconitine inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) in A549 cell through the inhibition of NF-κB nuclear translocation. Hypaconitine acts as the neuromuscular blocker. Hypaconitine is orally active.
    Hypaconitine
  • HY-N0663
    Talatisamine 20501-56-8 99.77%
    Talatisamine is an orally active cyclophilin D activator isolated from the roots of Aconitum carmichaeli Debx. Talatisamine exerts biological functions by activating cyclophilin D, inhibiting Ca2+-dependent opening of the mitochondrial permeability transition pore (mPTP) (IC50=78 μM), and blocking delayed rectifier K+ channels (IC50=146 μM). Talatisamine possesses both antioxidant and membrane-stabilizing properties, effectively inhibits lipid peroxidation and protects mitochondrial membrane function. Talatisamine exhibits multiple activities including antiarrhythmic, hypotensive, anti-inflammatory, anticancer and neuroprotective effects. Talatisamine finds applications in the research of ischemic diseases, rheumatoid arthritis, inflammation-related diseases and Alzheimer's disease.
    Talatisamine
  • HY-N17839
    Senbusine A 82202-95-7
    Senbusine A (compound 4) is a diterpenic alkaloid found in the dried roots of Aconitum carmichaeli from China. Senbusine A acts as an intermediate in the biosynthesis of aconitine.
    Senbusine A
  • HY-N17886
    Karacolidine 41655-13-4
    Karacolidine (compound 9) is an aconitine-type alkaloid. Karacolidine can be found in the lateral root of Aconitum carmichaeli Debx. (Radix Aconiti Lateralis).
    Karacolidine
  • HY-N17885
    16a,17-Dihydroxy lepenine 1443209-71-9
    16a,17-Dihydroxy lepenine (compound 1) is a C20 diterpenoid alkaloid with an atisine-denudatine skeleton. 16a,17-Dihydroxy lepenine can be isolated from the lateral roots of Aconitum carmichaelii.
    16a,17-Dihydroxy lepenine
  • HY-N0277
    Aconine 509-20-6 99.81%
    Aconine inhibits receptor activator of nuclear factor (NF)-κB ligand (RANKL)-induced NF-κB activation.
    Aconine
  • HY-N0724
    Mesaconitine 2752-64-9 99.19%
    Mesaconitine is a nitric oxide synthase activator. Mesaconitine drives extracellular Na+ and Ca2+ influx into endothelial cells, increases intracellular Na+ and Ca2+ concentrations, and triggers nitric oxide release. Mesaconitine is applicable for pain-related research.
    Mesaconitine
  • HY-N5025
    Bullatine A 1354-84-3 98.0%
    Bullatine A, a diterpenoid alkaloid, is a potent P2X7 antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting SIRT6. Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS (HY-D1056)-induced systemic inflammatory response by inhibiting the ROS/JNK/NF-κB pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress (CSDS) mice. Bullatine A can be used for the study of inflammation, glioblastoma (GBM) and depression.
    Bullatine A
  • HY-N0850
    Benzoylhypaconine 63238-66-4 99.73%
    Benzoylhypaconine (Benzoylhypacoitine) is a monoester Aconitum alkaloid, is the main pharmacologic and toxic component.
    Benzoylhypaconine
  • HY-N1974
    Fuziline 80665-72-1 99.65%
    Fuziline is a alkaloid isolated from the lateral roots of Aconitum carmichaelii.
    Fuziline
  • HY-N1924
    Crassicauline A 79592-91-9 98.78%
    Crassicauline A (Crassicaulin A) is a diester-type diterpenoid alkaloid. Crassicauline A exhibits feeding deterrent activity against adult Tribolium castaneum, with a EC50 of 1134.5 ppm. Crassicauline A induces arrhythmia at a dose of 0.10 mg/kg.
    Crassicauline A
  • HY-N2164
    3-Deoxyaconitine 3175-95-9 99.63%
    3-Deoxyaconitine a diterpenoid alkaloid, is a sodium channel activator.
    3-Deoxyaconitine
  • HY-N2162
    12-Epinapelline 110064-71-6 99.92%
    12-Epinapelline is a diterpene alkaloid isolated from Aconitum baikalense. 12-Epinapelline exhibits Anti-inflammatory activity and stimulates the growth of colonies from fibroblast precursors.
    12-Epinapelline
  • HY-N6812
    Karacoline 39089-30-0 99.58%
    Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway.
    Karacoline
  • HY-B1233
    Octodrine 543-82-8 ≥98.0%
    Octodrine (2-Amino-6-methylheptane) is a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Octodrine is found to increase the pain threshold, cardiac rate (positive chronotropic effect) and myocardial contractility (positive inotropic effect).
    Octodrine
  • HY-N9404
    6-Benzoylheteratisine 99759-48-5 99.58%
    6-Benzoylheteratisine is an Aconitum alkaloid with potential neuroprotective activity. 6-Benzoylheteratisine can antagonize tetrodotoxin, inhibit the increase of [Na+]i, [Ca2+]i and glutamate release, and block sodium channels. 6-Benzoylheteratisine has an inhibitory effect on the neuronal activity underlying epileptiform burst discharge.
    6-Benzoylheteratisine
  • HY-N7608
    Beiwutine 76918-93-9 98.94%
    Beiwutine (10-Hydroxy mesaconitine) is a diester diterpenoid alkaloid.
    Beiwutine