1. Immunology/Inflammation
    NF-κB
  2. COX
    NF-κB
  3. Esculentoside A

Esculentoside A 

Cat. No.: HY-N0632 Purity: 98.27%
Handling Instructions

Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta. Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models, has selective inhibitory activity towards cyclooxygenase-2 (COX-2). Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways.

For research use only. We do not sell to patients.

Esculentoside A Chemical Structure

Esculentoside A Chemical Structure

CAS No. : 65497-07-6

Size Price Stock Quantity
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
20 mg USD 230 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE Esculentoside A

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Description

Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta[1]. Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models[2], has selective inhibitory activity towards cyclooxygenase-2 (COX-2)[1]. Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways[3].

In Vitro

Esculentoside A (0-10 μM; 24 hours) reduced the release of TNF concentration in primed macrophages [4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Esculentoside A (EsA) (intraperitoneal injection; 20 mg/kg; once a day; 4 weeks) plays significant roles in the treatment of BXSB mice through modulation of inflammatory cytokines, inhibition of renal cell proliferation and induction of apoptosis [2].
Esculentoside A (EsA) (injected intraperitoneally; 5, 10 and 20 mg/kg; once a day; 7 days) dose-dependently decreases the TNF, IL-1 and IL-6 levels in the sera of mice following LPS challenge[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BXSB mice[2]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; 20 mg/kg; once a day; 4 weeks
Result: Alleviated the renal damage of LN.
Molecular Weight

826.96

Formula

C42H66O16

CAS No.
SMILES
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (120.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2092 mL 6.0462 mL 12.0925 mL
5 mM 0.2418 mL 1.2092 mL 2.4185 mL
10 mM 0.1209 mL 0.6046 mL 1.2092 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.02 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.02 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
Esculentoside A
Cat. No.:
HY-N0632
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