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  3. Esculentoside A

Esculentoside A 

Cat. No.: HY-N0632
Handling Instructions

Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta. Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models, has selective inhibitory activity towards cyclooxygenase-2 (COX-2). Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways.

For research use only. We do not sell to patients.

Esculentoside A Chemical Structure

Esculentoside A Chemical Structure

CAS No. : 65497-07-6

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Description

Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta[1]. Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models[2], has selective inhibitory activity towards cyclooxygenase-2 (COX-2)[1]. Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways[3].

In Vitro

Esculentoside A (0-10 μM; 24 hours) reduced the release of TNF concentration in primed macrophages [4].

In Vivo

Esculentoside A (EsA) (intraperitoneal injection; 20 mg/kg; once a day; 4 weeks) plays significant roles in the treatment of BXSB mice through modulation of inflammatory cytokines, inhibition of renal cell proliferation and induction of apoptosis [2].
Esculentoside A (EsA) (injected intraperitoneally; 5, 10 and 20 mg/kg; once a day; 7 days) dose-dependently decreases the TNF, IL-1 and IL-6 levels in the sera of mice following LPS challenge[4].

Animal Model: BXSB mice[2]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; 20 mg/kg; once a day; 4 weeks
Result: Alleviated the renal damage of LN.
Molecular Weight

826.96

Formula

C₄₂H₆₆O₁₆

CAS No.

65497-07-6

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Esculentoside A
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HY-N0632
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