2. Signaling Pathways
  3. Immunology/Inflammation
  4. Galectin

Galectin

Galectin

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Galectins comprise a family of soluble β-galactoside binding proteins, which regulate key biological processes including cell growth, differentiation, apoptosis, and immune responses.

Sixteen galectin genes have been identified in animal kingdoms, 12 of which are expressed in humans. Galectins are usually classified into three groups based on their structure: (i) prototypical galectins (galectin-1 (Gal1), Gal2, Gal5, Gal7, Gal10, Gal11, Gal 13, Gal14, and Gal15), characterized by a single CRD, which can act as monomers or form homodimers; (ii) the chimeric galectin Gal3 (the only member of this class), with a single CRD and a large amino-terminal domain that facilitates the formation of oligomers; (iii) the tandem repeat galectins, with two CRDs that are linked through a small peptide domain; this group includes Gal4, Gal6, Gal8, Gal9, and Gal12. Recently, Galectins have been implicated as major therapeutic determinants that confer sensitivity or resistance to a wide range of anticancer modalities including chemotherapy, radiotherapy, targeted therapies, antiangiogenic therapies, and immunotherapies.

Galectin Isoform Specific Products:

Galectin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-114409
    GB1107
    		Inhibitor 99.92%
    GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model.
    GB1107
  • HY-19940
    Olitigaltin
    		Inhibitor 99.74%
    TD139 is a synthetic galectin-3 inhibitor. TD139 has high affinity for galectin-3 with a Kd of 68 nM, a Kd of 0.22 μM for galectin-1, and a Kd of 38 μM for galectin-7.
    Olitigaltin
  • HY-19756
    OTX008
    		Inhibitor 99.94%
    OTX008 is a selective inhibitor of galectin-1.
    OTX008
  • HY-130208
    Thiodigalactoside
    		Inhibitor 99.97%
    Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats.
    Thiodigalactoside
  • HY-147041
    Selvigaltin
    		Inhibitor 99.89%
    Selvigaltin (GB1211) is an orally active galectin-3 small molecule inhibitor with an IC50 value of 12 nM in rabbits, showing anti-tumor activity. Selvigaltin decreases galectin-3 levels in the liver and reduces biomarkers of liver function (AST, ALT, bilirubin), inflammation (cells foci) and fibrosis (PSR, SHG), as well as decreasing the mRNA and protein expression of several key inflammation and fibrosis biomarkers (IL6, TGFβ3, SNAI2, collagen). Selvigaltin restores T-cell activity and induces less tumors and metastasis.
    Selvigaltin
  • HY-179410
    Galectin-3-IN-7
    		Inhibitor
    Galectin-3-IN-7 is a selective Galectin-3 inhibitor with a Kd of 5.7 nM and shows 390-fold selectivity over Gal-1. Galectin-3-IN-7 can downregulate profibrotic signaling such as ACTA2, COL1A2, and FN1 in TGFβ-stimulated LX2 hepatic stellate cells. Galectin-3-IN-7 can be used for the research of fibrosis.
    Galectin-3-IN-7
  • HY-181648
    Gal-1-IN-1
    		Inhibitor
    Gal-1-IN-1 is a potent and selective human galectin-1 (hGal-1) inhibitor with a Ki of 0.022 μM. Gal-1-IN-1 blocks hGal-1 binding to tumor cells and suppresses human galectin-1-induced pre-apoptosis state. Gal-1-IN-1 reduces hGal-1-expressing cancer cell viability. Gal-1-IN-1 can be used for the research of breast cancer.
    Gal-1-IN-1
  • HY-P992257
    Anti-LGALS3BP Antibody
    Anti-LGALS3BP Antibody is a monoclonal antibody targeting LGALS3BP. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LGALS3BP Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-LGALS3BP Antibody
  • HY-128852
    N-Acetyl-D-galactosamine, 98%
    		Inhibitor 99.85%
    N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets. N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin.
    N-Acetyl-D-galactosamine, 98%
  • HY-114440
    Belapectin
    		Inhibitor 98.94%
    Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM.
    Belapectin
  • HY-126854
    N-Acetyllactosamine
    		Inhibitor 99.95%
    N-Acetyllactosamine (N-Acetyl-D-lactosamine), a nitrogen-containing disaccharide, is a galectin-3 inhibitor, which is an important component of various oligosaccharides such as glycoproteins and sialyl Lewis X. N-Acetyllactosamine can be used as the starting material for the synthesis of various oligosaccharides. N-Acetyllactosamine has prebiotic effects.
    N-Acetyllactosamine
  • HY-W150340
    β-Lactose
    		Inhibitor 99.31%
    β-Lactose is a disaccharide commonly found in milk and dairy products. It consists of two monosaccharides, glucose and galactose, linked by β-glycosidic bonds. β-Lactose has various applications in the food industry, especially as a sweetener and bulking agent. Furthermore, it can be used as a substrate for enzymes involved in lactose metabolism and as a model compound for studying carbohydrate-protein interactions.
    β-Lactose
  • HY-P990242
    Anti-Mouse Galectin-9 Antibody (RG9-1)
    		Inhibitor
    Anti-Mouse Galectin-9 Antibody (RG9-1) is an anti-mouse Galectin-9 IgG2b monoclonal antibody. Anti-Mouse Galectin-9 Antibody (RG9-1) promotes inflammatory response by enhancing the secretion of IFN-γ, TNF-α, and IL-6. Anti-Mouse Galectin-9 Antibody (RG9-1) can increase CD8 T cell and Treg frequency. Anti-Mouse Galectin-9 Antibody (RG9-1) reduces graft survival time by increasing CD4+ and CD8+ T cell infiltration. Anti-Mouse Galectin-9 Antibody (RG9-1) can be used for researches on inflammation conditions, cancer and xenotransplantation such as ischemia-reperfusion, colon cancer, breast cancer and leukemia.
    Anti-Mouse Galectin-9 Antibody (RG9-1)
  • HY-N9497
    Galactinol
    		Ligand 99.92%
    Galactinol is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot.
    Galactinol
  • HY-P991228
    LYT-200
    		Inhibitor 99.16%
    LYT-200 is a humanized monoclonal antibody against galectin-9 (Galectin-9). LYT-200 binds to galectin-9 expressed on the surface of hematologic malignant cells, inhibits pro-leukemic functions and induces cell death. LYT-200 can be used in research related to hematologic malignancies.
    LYT-200
  • HY-135258
    Galactinol dihydrate
    		Ligand 98.0%
    Galactinol dihydrate is a disaccharide carbohydrate serving as a galactosyl donor, which belongs to the raffinose family oligosaccharide pathway and acts as an important osmoprotectant. Galactinol dihydrate not only induces disease resistance in plants against fungal and bacterial pathogens, but also significantly enhances plant tolerance to abiotic stresses such as drought, high salinity, low temperature and oxidative damage. In addition, Galactinol dihydrate has the ability to scavenge hydroxyl radicals, can act as a signaling component for root colonization-induced systemic resistance, and is positively correlated with seed longevity in various crops, making it a potential biomarker for evaluating seed vigor. Therefore, Galactinol dihydrate can be used in the research of various plant diseases including fungal leaf spot, bacterial angular leaf spot, gray mold and soft rot.
    Galactinol dihydrate
  • HY-162561
    GB1908
    		Inhibitor 98.94%
    GB1908 is a selective and orally active galectin-1 inhibitor with Ki values of 57 nM and 72 nM for human and mouse galectin-1, respectively. GB1908 displays >50-fold selectivity over galectin-3. GB1908 can be used for the study of lung cancer.
    GB1908
  • HY-146808
    Galectin-3 antagonist 1
    		Antagonist 98.95%
    Galectin-3 antagonist 1 (compound 15) is a potent and selective Galectin-3 (Gal-3) antagonist with Kd value of 5.3 μM. Meanwhile, Galectin-3 antagonist 1 binds to various Galectin with Kd values of 250 μM (Gal-4N), 18 μM (Gal-4C), 450 μM (Gal-8C), respectively.
    Galectin-3 antagonist 1
  • HY-P990198
    Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166)
    		Inhibitor
    Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166) is a rat-derived anti-mouse/human Mac-2/Galectin-3 IgG2a monoclonal antibody. Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166) significantly inhibits IL-6 expression (inhibition rates 34.7% and 55.3%). Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166) is often used for immunoprecipitation, western blot, immunofluorescence, and flow cytometry.
    Anti-Mouse/Human Mac-2/Galectin-3 Antibody (TIB-166)
  • HY-W340234
    4,5-Dibromo-2-pyrrolic acid
    		99.34%
    4,5-Dibromo-2-pyrrolic acid (compound 2) is an immunosuppressive compound. 4,5-Dibromo-2-pyrrolic acid suppresses the proliferative response of splenocytes to suboptimal concentrations of the mitogen, concanavalin A (Con A).
    4,5-Dibromo-2-pyrrolic acid
Cat. No. Product Name / Synonyms Application Reactivity
Galectin Isoform Comparison

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