1. Immunology/Inflammation
  2. Galectin
  3. GB1107

GB1107 

Cat. No.: HY-114409 Purity: 99.55%
Handling Instructions

GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model.

For research use only. We do not sell to patients.

GB1107 Chemical Structure

GB1107 Chemical Structure

CAS No. : 1978336-61-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 402 In-stock
Estimated Time of Arrival: December 31
5 mg USD 157 In-stock
Estimated Time of Arrival: December 31
10 mg USD 266 In-stock
Estimated Time of Arrival: December 31
25 mg USD 564 In-stock
Estimated Time of Arrival: December 31
50 mg USD 962 Get quote
100 mg USD 1665 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model[1].

IC50 & Target

Kd: 37 nM (human Gal-3)[1].

In Vitro

Treatment with GB1107 (0-1 μM) increases tumor M1 macrophage polarization and CD8+ T cell infiltration in LLC cells by flow cytometric analysis. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules[1].

In Vivo

GB1107 (10 mg/kg, p.o., once daily from day 18-30 post implantation) treatment results in significantly reduced tumor growth and final tumor weights[1].

Animal Model: CD-1 nude female mice received 3x106 human lung adenocarcinoma cells (A549)[1].
Dosage: 10 mg/kg
Administration: Oral once daily from day 18-30 post implantation.
Result: Resulted in significantly reduced tumor growth and final tumor weights.
Molecular Weight

522.32

Formula

C₂₀H₁₆Cl₂F₃N₃O₄S

CAS No.

1978336-61-6

SMILES

O[[email protected]]([[email protected]@H](N1N=NC(C2=CC(F)=C(F)C(F)=C2)=C1)[[email protected]]([[email protected]@H](CO)O3)O)[[email protected]]3SC4=CC=C(Cl)C(Cl)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (95.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9145 mL 9.5727 mL 19.1453 mL
5 mM 0.3829 mL 1.9145 mL 3.8291 mL
10 mM 0.1915 mL 0.9573 mL 1.9145 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.55%

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Keywords:

GB1107GB 1107GB-1107GalectinInhibitorinhibitorinhibit

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Product name:
GB1107
Cat. No.:
HY-114409
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