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GB1107 

Cat. No.: HY-114409
Handling Instructions

GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model.

For research use only. We do not sell to patients.

GB1107 Chemical Structure

GB1107 Chemical Structure

CAS No. : 1978336-61-6

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Description

GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model[1].

IC50 & Target

Kd: 37 nM (human Gal-3)[1].

In Vitro

Treatment with GB1107 (0-1 μM) increases tumor M1 macrophage polarization and CD8+ T cell infiltration in LLC cells by flow cytometric analysis. GB1107 potentiates the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFN-γ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules[1].

In Vivo

GB1107 (10 mg/kg, p.o., once daily from day 18-30 post implantation) treatment results in significantly reduced tumor growth and final tumor weights[1].

Animal Model: CD-1 nude female mice received 3x106 human lung adenocarcinoma cells (A549)[1].
Dosage: 10 mg/kg
Administration: Oral once daily from day 18-30 post implantation.
Result: Resulted in significantly reduced tumor growth and final tumor weights.
Molecular Weight

522.32

Formula

C₂₀H₁₆Cl₂F₃N₃O₄S

CAS No.

1978336-61-6

SMILES

O[[email protected]]([[email protected]@H](N1N=NC(C2=CC(F)=C(F)C(F)=C2)=C1)[[email protected]]([[email protected]@H](CO)O3)O)[[email protected]]3SC4=CC=C(Cl)C(Cl)=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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GB1107
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