1. Stem Cell/Wnt
  2. β-catenin


Cat. No.: HY-19940 Purity: 99.39%
Handling Instructions

TD139 is a novel high-affinity inhibitor of the galectin-3 carbohydrate binding domain with a Kd of 14 nM.

For research use only. We do not sell to patients.
TD139 Chemical Structure

TD139 Chemical Structure

CAS No. : 1450824-22-2

Size Price Stock Quantity
1 mg USD 80 In-stock
5 mg USD 160 In-stock
10 mg USD 260 In-stock
50 mg USD 940 In-stock
100 mg USD 1650 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation


TD139 is a novel high-affinity inhibitor of the galectin-3 carbohydrate binding domain with a Kd of 14 nM.

IC50 & Target

Kd: 14 nM (galectin-3)[1]

In Vitro

TD139 is a novel synthetic inhibitor of galectin-3. TD139 has high affinity for galectin-3 with a Kd of 14 nM and 10 nM for galectin-1, but low affinity for galectins 2, 4N, 4C, 7, 8N, or 9N[1].

In Vivo

In primary lung AECs TD139 reduces TGF-β1–induced β-catenin translocation to the nucleus, with most of the β-catenin remaining at the cell surface. TD139 blocks TGF-β1–induced β-catenin phosphorylation. A marked reduction in fibrosis and β-catenin activation accompanied by decreased galectin-3 expression is observed in the lungs of WT mice treated with TD139[1]. Pretreatment of WT C57BL/6 mice with TD139 leads to the attenuation of liver injury and milder infiltration of IFNγ- and IL-17- and -4-producing CD4(+) T cells, as well as an increase in the total number of IL-10-producing CD4(+) T cells and F4/80(+) CD206(+) alternatively activates macrophages and preventes the apoptosis of liver-infiltrating MNCs[2].

Clinical Trial
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.5417 mL 7.7084 mL 15.4169 mL
5 mM 0.3083 mL 1.5417 mL 3.0834 mL
10 mM 0.1542 mL 0.7708 mL 1.5417 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration

TD139 is prepared in saline.

Mice: The susceptibility to Con A-induced hepatitis in galectin-3-deficient mice is tested and the effects of pretreatment with a selective inhibitor of Gal-3 (TD139) in wild-type(WT) C57BL/6 mice are analyzed, as evaluated by a liver enzyme test, quantitative histology, mononuclear cell (MNC) infiltration, cytokine production, intracellular staining of immune cells, and percentage of apoptotic MNCs in the liver[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







O[[email protected]]([[email protected]@H](N1N=NC(C2=CC=CC(F)=C2)=C1)[[email protected]]([[email protected]@H](CO)O3)O)[[email protected]@H]3S[[email protected]]4[[email protected]@H]([[email protected]@H](N5N=NC(C6=CC=CC(F)=C6)=C5)[[email protected]]([[email protected]@H](CO)O4)O)O

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 1 mg/mL (Need ultrasonic); H2O: < 5 mg/mL; Ethanol: 0.1 mg/mL (Need ultrasonic and warming)

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

  • 竞价

Inquiry Online

Your information is safe with us. * Required Fields.

Product name



Applicant name *


Email address *

Phone number *


Organization name *

Country *


Requested quantity *


Bulk Inquiry

Inquiry Information

Product Name:
Cat. No.: