1450824-22-2
Chemical Structure
Olitigaltin
Synonym(s): TD139; GB0139
- CAS No.: 1450824-22-2
- Formula:C28H30F2N6O8S
- Molecular Weight:648.64
IUPAC Name: (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-thiobis(4-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diol)
InChIKey: YGIDGBAHDZEYMT-MQFIMZJJSA-N
SMILES: O[C@H]([C@@H](N1N=NC(C2=CC=CC(F)=C2)=C1)[C@H]([C@@H](CO)O3)O)[C@@H]3S[C@H]4[C@@H]([C@@H](N5N=NC(C6=CC=CC(F)=C6)=C5)[C@H]([C@@H](CO)O4)O)O
Biological Activity: Olitigaltin (TD139) is a high-affinity Galectin-3 inhibitor with a Kd value of 14 nM. Olitigaltin inhibits the activity of the AKT/β-catenin pathway, induces Apoptosis, and downregulates SREBP1 expression. Olitigaltin enhances the phosphorylation level of ERK. Olitigaltin alleviates bleomycin (HY-17565A)-induced advanced pulmonary fibrosis in mice. Olitigaltin delays the onset of diabetes, and improves glucose tolerance and serum insulin levels. Olitigaltin alleviates liver injury. Olitigaltin maintains the structure of hippocampal excitatory synapses, restores γ-wave power in the hippocampal CA1 region, inhibits hippocampal neuroinflammation, and improves cognitive function in neuroinflammation models. Olitigaltin can be used in research related to thyroid cancer, idiopathic pulmonary fibrosis, type 1 diabetes, hepatitis, and cognitive dysfunction induced by neuroinflammation[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Olitigaltin | 99.74% | Olitigaltin (TD139) is a high-affinity Galectin-3 inhibitor with a Kd value of 14 nM. Olitigaltin inhibits the activity of the AKT/β-catenin pathway, induces Apoptosis, and downregulates SREBP1 expression. Olitigaltin enhances the phosphorylation level of ERK. Olitigaltin alleviates bleomycin (HY-17565A)-induced advanced pulmonary fibrosis in mice. Olitigaltin delays the onset of diabetes, and improves glucose tolerance and serum insulin levels. Olitigaltin alleviates liver injury. Olitigaltin maintains the structure of hippocampal excitatory synapses, restores γ-wave power in the hippocampal CA1 region, inhibits hippocampal neuroinflammation, and improves cognitive function in neuroinflammation models. Olitigaltin can be used in research related to thyroid cancer, idiopathic pulmonary fibrosis, type 1 diabetes, hepatitis, and cognitive dysfunction induced by neuroinflammation. | ||||||||||||||||||||
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Olitigaltin (Standard) | ≥98% | Olitigaltin (Standard) is the analytical standard of Olitigaltin (HY-19940). This product is intended for research and analytical applications. TD139 is a synthetic galectin-3 inhibitor. TD139 has high affinity for galectin-3 with a Kd of 68 nM, a Kd of 0.22 μM for galectin-1, and a Kd of 38 μM for galectin-7. | ||||||||||||||||||||
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References
- [1]. Lee JJ, et al. Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells. International journal of endocrinology. 2021;2021:5583491. [Content Brief]
- [2]. Mackinnon AC, et al. Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. American journal of respiratory and critical care medicine. 2012 Mar 01;185(5):537-46. [Content Brief]
- [3]. Huang TS, et al. Regulation of Expression of Sterol Regulatory Element-binding Protein 1 in Thyroid Cancer Cells. Anticancer research. 2022 May;42(5):2487-2493. [Content Brief]
- [4]. Xie L, et al. Galectin-3 exacerbates autoimmune diabetes by limiting regulatory T cell differentiation and function. Science advances. 2026 Jan 02;12(1):eadz7916.
- [5]. Volarevic V, et al. Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice. Hepatology (Baltimore, Md.). 2012 Jun;55(6):1954-64. [Content Brief]
- [6]. Wu HP, et al. Galectin-3 in microglia mediates neuroinflammation-induced cognitive dysfunction via selective elimination of excitatory synapses in hippocampal CA1. Brain research. 2026 Sep 15;1887:150382. [Content Brief]
