2. Immunology/Inflammation
  3. Galectin
  4. G3-C12

G3-C12 is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

G3-C12 Chemical Structure

G3-C12 Chemical Structure

CAS No. : 848301-94-0

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5 mg USD 180 In-stock
10 mg USD 280 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of G3-C12:

G3-C12 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE G3-C12

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

G3-C12 is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity.

IC50 & Target

Galectin-3

 

In Vitro

G3-C12 is a galectin-3 binding peptide, with high affinity (Kd) of 88 nM, but shows no affinity for other galectin family members or to other lectins. G3-C12 bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA) potently and selectively targets colorectal cancer (CRC) tumour cells over-expressing galectin-3 and displays superior targetability to galectin-3 compared to the galactose bearing copolymer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

G3-C12 Related Antibodies
Molecular Weight

1758.98

Formula

C74H115N23O23S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ala-Asn-Thr-Pro-Cys-Gly-Pro-Tyr-Thr-His-Asp-Cys-Pro-Val-Lys-Arg
Sequence Shortening

ANTPCGPYTHDCPVKR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (56.85 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5685 mL 2.8426 mL 5.6851 mL
5 mM 0.1137 mL 0.5685 mL 1.1370 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.44%

COA (242 KB) LCMS (118 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5685 mL 2.8426 mL 5.6851 mL 14.2128 mL
5 mM 0.1137 mL 0.5685 mL 1.1370 mL 2.8426 mL
10 mM 0.0569 mL 0.2843 mL 0.5685 mL 1.4213 mL
15 mM 0.0379 mL 0.1895 mL 0.3790 mL 0.9475 mL
20 mM 0.0284 mL 0.1421 mL 0.2843 mL 0.7106 mL
25 mM 0.0227 mL 0.1137 mL 0.2274 mL 0.5685 mL
30 mM 0.0190 mL 0.0948 mL 0.1895 mL 0.4738 mL
40 mM 0.0142 mL 0.0711 mL 0.1421 mL 0.3553 mL
50 mM 0.0114 mL 0.0569 mL 0.1137 mL 0.2843 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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G3-C12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G3-C12848301-94-0GalectinInhibitorinhibitorinhibit

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