N-Acetyl-D-galactosamine, 98%
Based on 1 Customer Validation
N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets. N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin.
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 14215-68-0
- Formula: C8H15NO6
- Molecular Weight:221.21
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Human Endogenous Metabolite |
N-Acetyl-D-galactosamine (GalNAc) (50nm; 4 hours) decreases the expression of occludin mRNA and claudin-3 mRNA by 1.6% and 2.7%[1]. N-Acetyl-D-galactosamine (GalNAc) (50nm; 4 hours) lowers the protein expression of occludin and claudin-3 by 4.3% and 7.2%, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IPEC-J2 cell
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Concentration:50 nM
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Incubation Time:4 hours
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Result:Observed a slight reduction in mRNA expression of occludin and claudin-3.
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Cell Line:IPEC-J2 cell
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Concentration:50 nM
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Incubation Time:4 hours
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Result:Alleviated the damage of tight junction expressions at protein level.
Chemical Information
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CAS No. 14215-68-0
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Appearance Solid
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Molecular Weight 221.21
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Formula C8H15NO6
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Color White to off-white
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SMILES
CC(N[C@@H]1[C@H]([C@H]([C@H](O[C@@H]1O)CO)O)O)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 125 mg/mL (565.07 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhao B, et al. N-Acetyl-d-galactosamine prevents soya bean agglutinin-induced intestinal barrier dysfunction in intestinal porcine epithelial cells. J Anim Physiol Anim Nutr (Berl). 2019 Jul;103(4):1198-1206. [Content Brief]
[2]. Sadanandan R, et al. Isolation, Purification and Characterisation of a D-galactose and N-acetyl-D-galactosamineSpecific Lectin from Marine Sponge Fasciospongia cavernosa. Protein Pept Lett. 2018;25(9):871-877. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.5206 mL | 22.6030 mL | 45.2059 mL | 113.0148 mL |
| 5 mM | 0.9041 mL | 4.5206 mL | 9.0412 mL | 22.6030 mL | |
| 10 mM | 0.4521 mL | 2.2603 mL | 4.5206 mL | 11.3015 mL | |
| 15 mM | 0.3014 mL | 1.5069 mL | 3.0137 mL | 7.5343 mL | |
| 20 mM | 0.2260 mL | 1.1301 mL | 2.2603 mL | 5.6507 mL | |
| 25 mM | 0.1808 mL | 0.9041 mL | 1.8082 mL | 4.5206 mL | |
| 30 mM | 0.1507 mL | 0.7534 mL | 1.5069 mL | 3.7672 mL | |
| 40 mM | 0.1130 mL | 0.5651 mL | 1.1301 mL | 2.8254 mL | |
| 50 mM | 0.0904 mL | 0.4521 mL | 0.9041 mL | 2.2603 mL | |
| 60 mM | 0.0753 mL | 0.3767 mL | 0.7534 mL | 1.8836 mL | |
| 80 mM | 0.0565 mL | 0.2825 mL | 0.5651 mL | 1.4127 mL | |
| 100 mM | 0.0452 mL | 0.2260 mL | 0.4521 mL | 1.1301 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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