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  3. N-​Acetyl-​d-​galactosamine

N-​Acetyl-​d-​galactosamine (Synonyms: GalNAc)

Cat. No.: HY-128852
Handling Instructions

N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets. N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin.

For research use only. We do not sell to patients.

N-​Acetyl-​d-​galactosamine Chemical Structure

N-​Acetyl-​d-​galactosamine Chemical Structure

CAS No. : 14215-68-0

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Description

N-Acetyl-D-galactosamine (GalNAc) is a terminal essential amino sugar derived from galactose and forms the antigens of blood group A in humans. N-Acetyl-D-galactosamine (GalNAc) interact with Soya bean agglutinin (SBA), hence decreasing the effects of SBA on cellular membrane permeability and tight junction protein expression in piglets[1]. N-Acetyl-D-galactosamine (GalNAc) inhibits the hemagglutinating activity by the lectin[2].

In Vitro

N-Acetyl-D-galactosamine (GalNAc) (50nm; 4 hours) decreases the expression of occludin mRNA and claudin-3 mRNA by 1.6% and 2.7%[1].
N-Acetyl-D-galactosamine (GalNAc) (50nm; 4 hours) lowers the protein expression of occludin and claudin-3 by 4.3% and 7.2%, respectively[1].

RT-PCR[1]

Cell Line: IPEC-J2 cell
Concentration: 50 nM
Incubation Time: 4 hours
Result: Observed a slight reduction in mRNA expression of occludin and claudin-3.

Western Blot Analysis[1]

Cell Line: IPEC-J2 cell
Concentration: 50 nM
Incubation Time: 4 hours
Result: Alleviated the damage of tight junction expressions at protein level.
Molecular Weight

221.21

Formula

C₈H₁₅NO₆

CAS No.

14215-68-0

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (565.07 mM; Need ultrasonic)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5206 mL 22.6030 mL 45.2059 mL
5 mM 0.9041 mL 4.5206 mL 9.0412 mL
10 mM 0.4521 mL 2.2603 mL 4.5206 mL
*Please refer to the solubility information to select the appropriate solvent.
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Product Name:
N-​Acetyl-​d-​galactosamine
Cat. No.:
HY-128852
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