Dehydromiltirone  (Synonyms: 1,2-Didehydromiltirone)

Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research^[1][2].

Dehydromiltirone (100 μg/mL; for 24 h) inhibits p38 and NF-κB signaling in Kupffer cells^[1].
Dehydromiltirone inhibits the expression of osteoclast-associated genes, including NFATc1, CTSK, c-Fos, Acp5, and MMP9; and the phosphorylation of P38, ERK, and JNK of the MAPK signaling pathway; and the degradation of IκB-α of NF-κB signaling pathway. Dehydromiltirone exhibits an anti-osteoclastogenesis effect by reducing the expression of related genes, ultimately inhibiting bone resorption in vitro^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dehydromiltirone (50-200 mg/kg, p.o.; daily; for five consecutive days) protects the liver from CCl4-induced injury. Dehydromiltirone reduces the increase in the proinflammatory cytokines TNF-α, IL-1 and IL-6, indicating an effect on alleviating liver inflammation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

280.36

C₁₉H₂₀O₂

116064-77-8

O=C1C(C(C)C)=CC2=C(C3=C(C=C2)C(C)(C)CC=C3)C1=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Shuqiang Yue, et al. Salvia miltiorrhiza compounds protect the liver from acute injury by regulation of p38 and NFκB signaling in Kupffer cells. Pharm Biol. 2014 Oct;52(10):1278-85.  [Content Brief]

  [2]. Wei Deng, et al. Dehydromiltirone inhibits osteoclast differentiation in RAW264.7 and bone marrow macrophages by modulating MAPK and NF-κB activity. Front Pharmacol. 2022 Sep 21;13:1015693.  [Content Brief]