1. NF-κB MAPK/ERK Pathway
  2. NF-κB p38 MAPK
  3. Dehydromiltirone

Dehydromiltirone  (Synonyms: 1,2-Didehydromiltirone)

Cat. No.: HY-122961
Handling Instructions

Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research.

For research use only. We do not sell to patients.

Dehydromiltirone Chemical Structure

Dehydromiltirone Chemical Structure

CAS No. : 116064-77-8

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Description

Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research[1][2].

In Vitro

Dehydromiltirone (100 μg/mL; for 24 h) inhibits p38 and NF-κB signaling in Kupffer cells[1].
Dehydromiltirone inhibits the expression of osteoclast-associated genes, including NFATc1, CTSK, c-Fos, Acp5, and MMP9; and the phosphorylation of P38, ERK, and JNK of the MAPK signaling pathway; and the degradation of IκB-α of NF-κB signaling pathway. Dehydromiltirone exhibits an anti-osteoclastogenesis effect by reducing the expression of related genes, ultimately inhibiting bone resorption in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Kupffer cells
Concentration: 100 μg/mL
Incubation Time: For 24 h
Result: Significantly decreased p38 and p-p38 levels, NF-κBp65, IκB, and c-fos protein levels.
In Vivo

Dehydromiltirone (50-200 mg/kg, p.o.; daily; for five consecutive days) protects the liver from CCl4-induced injury. Dehydromiltirone reduces the increase in the proinflammatory cytokines TNF-α, IL-1 and IL-6, indicating an effect on alleviating liver inflammation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat model of acute liver injury[1]
Dosage: 50 mg/kg, 100 mg/kg, and 200 mg/kg
Administration: p.o.; daily; for five consecutive days
Result: Protected liver from CCl4-induced damage.
Molecular Weight

280.36

Formula

C19H20O2

CAS No.
SMILES

O=C1C(C(C)C)=CC2=C(C3=C(C=C2)C(C)(C)CC=C3)C1=O

Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Dehydromiltirone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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