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Rademikibart

(Synonyms: CBP-201)
Customer Review

Based on 1 Customer Validation

Rademikibart (CBP-201) is a human monoclonal antibody targeting IL-4Rα and IL-4Rα inhibitor with a KD of 20.7 pM when binding to human IL-4Rα epitopes. Rademikibart does not bind to IL-4Rα from other species. Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation and thymus activation regulated chemokine (TRAC) production. Rademikibart can be used for the research of atopic dermatitis and asthma.

For research use only. We do not sell to patients.

  • Purity: 99.13%
  • CAS No.: 2648260-80-2
  • Molecular Weight:145.36 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Rademikibart
  • Experimental Validation Results for Rademikibart
  • Experimental Validation Results for Rademikibart
  • Rademikibart Chemical Structure
    Rademikibart Chemical Structure
CAS No.: 2648260-80-2
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Rademikibart Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized IL-4R alpha/CD124 Protein, Human can bind Rademikibart. The EC50 for this effect is 4.99 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 Ramos cells with Rademikibart (HY-P990090, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Rademikibart Chemical Structure
    1/16
  • Rademikibart
  • Immobilized IL-4R alpha/CD124 Protein, Human can bind Rademikibart. The EC50 for this effect is 4.99 ng/mL.
  • Flow cytometric analysis of 1.5×106 Ramos cells with Rademikibart (HY-P990090, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).