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  3. Asperulosidic Acid

Asperulosidic Acid 

Cat. No.: HY-N6246
Handling Instructions

Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways.

For research use only. We do not sell to patients.

Asperulosidic Acid Chemical Structure

Asperulosidic Acid Chemical Structure

CAS No. : 25368-11-0

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Description

Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities[1]. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways[2].

In Vitro

Asperulosidic Acid (ASPA) (40-160 μg/mL; pre- 1 hour) significantly down-regulates the mRNA levels of TNF-α and IL-6 in LPS-induced RAW 264.7 cells compared with the group treated with LPS alone [1].
Asperulosidic Acid (ASPA) (40-160 μg/mL; pre- 1 hour) decreases IκB-α phosphorylation in a concentration-dependent manner, decreases Erk1/2 phosphorylation at all concentration levels, but there was no effect on p-p38 [1].

RT-PCR[2]

Cell Line: RAW 264.7 cells
Concentration: 40 μg/mL, 80 μg/mL, and 160 μg/mL
Incubation Time: Pre-treatment 1 hour
Result: Decreased TNF-α and IL-6 mRNA expression.

Western Blot Analysis[2]

Cell Line: RAW 264.7 cells
Concentration: 40 μg/mL, 80 μg/mL, and 160 μg/mL
Incubation Time: Pre-treatment 1 hour
Result: Decreased IκB-α phosphorylation and Erk1/2 phosphorylation.
Molecular Weight

432.38

Formula

C₁₈H₂₄O₁₂

CAS No.

25368-11-0

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Asperulosidic Acid
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