1. Immunology/Inflammation
    NF-κB
  2. COX
    NF-κB

Guaiacol (Synonyms: 2-Methoxyphenol)

Cat. No.: HY-N1380
Handling Instructions

Guaiacol, a phenolic compound isolated from Guaiac resin, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Anti-inflammatory activity.

For research use only. We do not sell to patients.

Guaiacol Chemical Structure

Guaiacol Chemical Structure

CAS No. : 90-05-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • References

Description

Guaiacol, a phenolic compound isolated from Guaiac resin, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[1].

IC50 & Target[1]

COX-2

 

NF-κB

 

In Vitro

Guaiacol inhibits LPS-stimulated nuclear factor kappa B (NF-κB) activation and cyclooxygenase (COX)-2 gene expression in cells of the RAW 264.7 murine macrophage cell line. Phenolic compounds such as Phenol, Eugenol, Guaiacol and Vanillin inhibit sheep vesicular gland prostaglandin cyclooxygenase, as indicated by their 50% inhibition concentrations, which decline in the following order: Phenol (1600 μM) > Vanillin (>500 μM) > Guaiacol (72 μM) > Eugenol (12 μM)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.0554 mL 40.2771 mL 80.5542 mL
5 mM 1.6111 mL 8.0554 mL 16.1108 mL
10 mM 0.8055 mL 4.0277 mL 8.0554 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

124.14

Formula

C₇H₈O₂

CAS No.

90-05-1

SMILES

OC1=CC=CC=C1OC

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Guaiacol
Cat. No.:
HY-N1380
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Guaiacol

Cat. No.: HY-N1380