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Cat. No.: HY-N2181A

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DL-Acetylshikonin

DL-Acetylshikonin is a non-selective, reversible cytochrome P450 inhibitor with IC₅₀ values of 1.4-4.0 μM. DL-Acetylshikonin has anti-cancer and anti-inflammatory activities.

For research use only. We do not sell to patients.

CAS No.: 54984-93-9
Formula: C₁₈H₁₈O₆
Molecular Weight:330.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

DL-Acetylshikonin Chemical Structure

CAS No.: 54984-93-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

DL-Acetylshikonin is a non-selective, reversible cytochrome P450 inhibitor with IC₅₀ values of 1.4-4.0 μM. DL-Acetylshikonin has anti-cancer and anti-inflammatory activities^[1].

IC₅₀ & Target^[1]

CYP2C8

1.4 μM (IC₅₀)

CYP2B6

2.0 μM (IC₅₀)

CYP3A

2.3 μM (IC₅₀)

CYP2C19

2.5 μM (IC₅₀)

CYP2D6

2.5 μM (IC₅₀)

CYP2E1

2.7 μM (IC₅₀)

CYP2C9

3.3 μM (IC₅₀)

CYP2J2

3.3 μM (IC₅₀)

CYP2A6

3.8 μM (IC₅₀)

CYP1A2

4.0 μM (IC₅₀)

All Cytochrome P450 Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RD	CC₅₀	9.4 μM Compound: AS	Cytotoxicity against human RD cells assessed as reduction in cell viability after 12 hrs by CCK8 assay Cytotoxicity against human RD cells assessed as reduction in cell viability after 12 hrs by CCK8 assay	[PMID: 31063370]

In Vitro

DL-Acetylshikonin inhibits CYP3A-mediated testosterone and Nifedipine (HY-B0284) metabolism with IC₅₀ values of 5.2 μM and 3.0 μM, respectively, indicating that it inhibits CYP3A activity in a substrate-independent manner^[1].
DL-Acetylshikonin is not a time-dependent inhibitor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 54984-93-9
Molecular Weight 330.33
Formula C₁₈H₁₈O₆
SMILES

C/C(C)=C\CC(OC(C)=O)C1=CC(C2=C(O)C=CC(O)=C2C1=O)=O
Structure Classification
- Quinones
- Naphthalene Quinones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shon JC, et al. Acetylshikonin is a novel non-selective cytochrome P450 inhibitor. Biopharm Drug Dispos. 2017 Dec;38(9):553-556. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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DL-Acetylshikonin

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DL-Acetylshikonin Related Classifications

HY-N2181A Related Classifications