2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. DL-Acetylshikonin

DL-Acetylshikonin is a non-selective, reversible cytochrome P450 inhibitor with IC50 values of 1.4-4.0 μM. DL-Acetylshikonin has anti-cancer and anti-inflammatory activities.

For research use only. We do not sell to patients.

DL-Acetylshikonin Chemical Structure

DL-Acetylshikonin Chemical Structure

CAS No. : 54984-93-9

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Other Forms of DL-Acetylshikonin:

DL-Acetylshikonin Related Antibodies

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View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP3A4 CYP17A1

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Description

DL-Acetylshikonin is a non-selective, reversible cytochrome P450 inhibitor with IC50 values of 1.4-4.0 μM. DL-Acetylshikonin has anti-cancer and anti-inflammatory activities[1].

IC50 & Target[1]

CYP2C8

1.4 μM (IC50)

CYP2B6

2.0 μM (IC50)

CYP3A

2.3 μM (IC50)

CYP2C19

2.5 μM (IC50)

CYP2D6

2.5 μM (IC50)

CYP2E1

2.7 μM (IC50)

CYP2C9

3.3 μM (IC50)

CYP2J2

3.3 μM (IC50)

CYP2A6

3.8 μM (IC50)

CYP1A2

4.0 μM (IC50)

In Vitro

DL-Acetylshikonin inhibits CYP3A-mediated testosterone and Nifedipine (HY-B0284) metabolism with IC50 values of 5.2 μM and 3.0 μM, respectively, indicating that it inhibits CYP3A activity in a substrate-independent manner[1].
DL-Acetylshikonin is not a time-dependent inhibitor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DL-Acetylshikonin Related Antibodies
Molecular Weight

330.33

Formula

C18H18O6
CAS No.
SMILES

C/C(C)=C\CC(OC(C)=O)C1=CC(C2=C(O)C=CC(O)=C2C1=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DL-Acetylshikonin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-Acetylshikonin54984-93-9Cytochrome P450CYPsanti-canceranti-inflammatoryCYPInhibitorinhibitorinhibit

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