2. Anti-infection NF-κB Apoptosis
  3. NF-κB Bacterial Antibiotic Apoptosis
  4. Tylvalosin tartrate

Tylvalosin tartrate  (Synonyms: Acetylisovaleryltylo​sin tartrate)

Cat. No.: HY-128423 Purity: 98.77%
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Tylvalosin (Acetylisovaleryltylosin) tartrate is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin tartrate is an antiviral agent useful in studying PRRSV infection. Tylvalosin tartrate induces apoptosis. Tylvalosin tartrate also has anti-inflammatory activity, relieves oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation.

For research use only. We do not sell to patients.

Tylvalosin tartrate Chemical Structure

Tylvalosin tartrate Chemical Structure

CAS No. : 63428-13-7

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Other Forms of Tylvalosin tartrate:

Tylvalosin tartrate Related Antibodies

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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Description

Tylvalosin (Acetylisovaleryltylosin) tartrate is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin tartrate is an antiviral agent useful in studying PRRSV infection. Tylvalosin tartrate induces apoptosis. Tylvalosin tartrate also has anti-inflammatory activity, relieves oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation[1][2][3][4].

IC50 & Target

Macrolide

 

In Vitro

Tylvalosin tartrate (10 μg/mL; 0.5, 1 h) increases caspase-3 cleavage in porcine neutrophils, leading to DNA fragmentation during apoptosis [4].
Tylvalosin tartrate (0.1-10 μg/mL; 0.5 h) Promote endocytosis of porcine neutrophils by macrophages without changing phagocytosis [4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tylvalosin tartrate Related Antibodies

Apoptosis Analysis[4]

Cell Line: Porcine neutrophils
Concentration: 0.1, 1.0, or 10 µg/mL
Incubation Time: 0.5, 1 h
Result: Resulted induction of concentration- and time-dependent apoptosis in porcine monocyte-derived macrophages.
In Vivo

Tylvalosin tartrate (160 mg/kg; po; 7 d) can reduce the stress state of pigs during the immunization process with PRRSV inactivated vaccine and improve the health of pig[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PRRSV-free commercial breed piglets[5]
Dosage: 800 mg/kg Aivlosin (20% Tylvalosin Tartrate Premix)
Administration: po; 7-14 days
Result: Attenuated the increase in total white blood cells induced by immunization at day one post-immunization (DPI) and induced an increase in monocyte counts after seven DPI.
Attenuate the reduction in the percentage of CD8+ T cells induced by PRRSV-inactivated vaccine immunization at seven DPI.
Molecular Weight

1192.34

Formula

C57H93NO25
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

OC([C@H](O)[C@@H](O)C(O)=O)=O.O[C@@H]1[C@@H](C)O[C@@H](OC[C@H]([C@@H](CC)OC(C[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC(CC(C)C)=O)[C@@](O)(C)C3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@H]4C)=O)/C=C(C)/C=C/C4=O)[C@H](OC)[C@@H]1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (83.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8387 mL 4.1934 mL 8.3869 mL
5 mM 0.1677 mL 0.8387 mL 1.6774 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (2.10 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (2.10 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 98.77%

COA (263 KB) HNMR (374 KB) LCMS (106 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8387 mL 4.1934 mL 8.3869 mL 20.9672 mL
5 mM 0.1677 mL 0.8387 mL 1.6774 mL 4.1934 mL
10 mM 0.0839 mL 0.4193 mL 0.8387 mL 2.0967 mL
15 mM 0.0559 mL 0.2796 mL 0.5591 mL 1.3978 mL
20 mM 0.0419 mL 0.2097 mL 0.4193 mL 1.0484 mL
25 mM 0.0335 mL 0.1677 mL 0.3355 mL 0.8387 mL
30 mM 0.0280 mL 0.1398 mL 0.2796 mL 0.6989 mL
40 mM 0.0210 mL 0.1048 mL 0.2097 mL 0.5242 mL
50 mM 0.0168 mL 0.0839 mL 0.1677 mL 0.4193 mL
60 mM 0.0140 mL 0.0699 mL 0.1398 mL 0.3495 mL
80 mM 0.0105 mL 0.0524 mL 0.1048 mL 0.2621 mL
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Tylvalosin tartrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tylvalosin63428-13-7Acetylisovaleryltylo​sinNF-κBBacterialAntibioticApoptosisNuclear factor-κBNuclear factor-kappaBMacrolideveterinaryantibioticGram-positiveInhibitorinhibitorinhibit

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