2. Anti-infection NF-κB Apoptosis
  3. Antibiotic Bacterial NF-κB Apoptosis
  4. Tylvalosin

Tylvalosin  (Synonyms: Acetylisovaleryltylo​sin)

Cat. No.: HY-128423A Purity: ≥96.0%
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Tylvalosin (Acetylisovaleryltylo?sin) is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin is an antiviral agent used to study PRRSV infection. Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, alleviates oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation.

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Tylvalosin Chemical Structure

Tylvalosin Chemical Structure

CAS No. : 63409-12-1

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Description

Tylvalosin (Acetylisovaleryltylo?sin) is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin is an antiviral agent used to study PRRSV infection. Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, alleviates oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation[1][2][3].

In Vitro

Tylvalosin (10 μg/mL; 0.5, 1 h) increases caspase-3 cleavage in porcine neutrophils, leading to DNA fragmentation during apoptosis[4].
Tylvalosin (0.1-10 μg/mL; 0.5 h) promotes endocytosis of porcine neutrophils by macrophages without changing phagocytosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tylvalosin Related Antibodies

Apoptosis Analysis[4]

Cell Line: Porcine neutrophils
Concentration: 0.1, 1.0, or 10 µg/mL
Incubation Time: 0.5, 1 h
Result: Resulted induction of concentration- and time-dependent apoptosis in porcine monocyte-derived macrophages.
In Vivo

Tylvalosin tartrate (160 mg/kg; po; 7 d) can reduce the stress state of pigs during the immunization process with PRRSV inactivated vaccine and improve the health of pig[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PRRSV-free commercial breed piglets[5]
Dosage: 800 mg/kg Aivlosin (20% Tylvalosin Tartrate Premix)
Administration: po; 7-14 days
Result: Attenuated the increase in total white blood cells induced by immunization at day one post-immunization (DPI) and induced an increase in monocyte counts after seven DPI.
Attenuate the reduction in the percentage of CD8+ T cells induced by PRRSV-inactivated vaccine immunization at seven DPI.
Molecular Weight

1042.25

Formula

C53H87NO19
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@@H](C)O[C@@H](OC[C@H]([C@@H](CC)OC(C[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC(CC(C)C)=O)[C@@](O)(C)C3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@H]4C)=O)/C=C(C)/C=C/C4=O)[C@H](OC)[C@@H]1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥96.0%

COA (258 KB)

Handling Instructions (2659 KB)
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Tylvalosin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tylvalosin63409-12-1Acetylisovaleryltylo​sinAntibioticBacterialNF-κBApoptosisNuclear factor-κBNuclear factor-kappaBinflammatoryPRRSV infectionantiviralacute lung injuryporcine neutrophilsmacrophagesInhibitorinhibitorinhibit

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