Etoricoxib-d4
Based on 1 publication(s) in Google Scholar
Etoricoxib-d4 (MK-0663-d4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.
For research use only. We do not sell to patients.
- Purity: 98.82%
- CAS No.: 1131345-14-6
- Formula: C18H11D4ClN2O2S
- Molecular Weight:362.87
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Etoricoxib-d4
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1131345-14-6
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Unlabeled Cas 202409-33-4
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Appearance Solid
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Molecular Weight 362.87
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Formula C18H11D4ClN2O2S
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Color Light yellow to yellow
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SMILES
ClC(C=N1)=CC(C2=C([2H])C([2H])=C(S(C)(=O)=O)C([2H])=C2[2H])=C1C3=CN=C(C)C=C3
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Synonyms
MK-0663-d4; L-791456-d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 100 mg/mL (275.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (251 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7558 mL | 13.7790 mL | 27.5581 mL | 68.8952 mL |
| 5 mM | 0.5512 mL | 2.7558 mL | 5.5116 mL | 13.7790 mL | |
| 10 mM | 0.2756 mL | 1.3779 mL | 2.7558 mL | 6.8895 mL | |
| 15 mM | 0.1837 mL | 0.9186 mL | 1.8372 mL | 4.5930 mL | |
| 20 mM | 0.1378 mL | 0.6890 mL | 1.3779 mL | 3.4448 mL | |
| 25 mM | 0.1102 mL | 0.5512 mL | 1.1023 mL | 2.7558 mL | |
| 30 mM | 0.0919 mL | 0.4593 mL | 0.9186 mL | 2.2965 mL | |
| 40 mM | 0.0689 mL | 0.3445 mL | 0.6890 mL | 1.7224 mL | |
| 50 mM | 0.0551 mL | 0.2756 mL | 0.5512 mL | 1.3779 mL | |
| 60 mM | 0.0459 mL | 0.2297 mL | 0.4593 mL | 1.1483 mL | |
| 80 mM | 0.0344 mL | 0.1722 mL | 0.3445 mL | 0.8612 mL | |
| 100 mM | 0.0276 mL | 0.1378 mL | 0.2756 mL | 0.6890 mL |
Etoricoxib-d4 Related Classifications
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