Meglumine
Based on 1 Customer Validation
Meglumine (Methylglucamine) is an orally active amino sugar derived from sorbitol. Meglumine has anti-inflammatory and antitumor activity. Meglumine is often used as an excipient in active molecules and with iodinated compounds in contrast agents such as meglumine and meglumine iodide.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 6284-40-8
- Formula: C7H17NO5
- Molecular Weight:195.21
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Meglumine (40 or 80 mM, 24 h; 50 mM, 24 h) dose-dependently reduces the levels of inflammatory factors in THP-1 human myeloid cells and RAW264.7 mouse macrophage cells (Elisa assay)[2].
Meglumine (0-300 mM, 60 min) dose-dependently increases SNARK expression levels in C2C12 mouse myoblasts[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:C2C12 mouse myoblasts
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Concentration:0, 10, 30, 100, 300 mM or 200 mM
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Incubation Time:60 min or 0, 10, 30, 60, 120 min
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Result:Increased the levels of SNARK protein in a dose-dependent manner after 60 min and reached a plateau at 30 minutes.
Meglumine (18 mM, oral gavage) improves muscle function, limits metabolic syndrome, and reduces diabetic complications in type 2 diabetic mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rat[2]
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Dosage:25 or 50 mM
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Administration:p.o., dissolve in water
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Result:Reduced the isoprostane levels in rats.
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Animal Model:K6/ODC transgenic mice[2]
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Dosage:37.5 mM
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Administration:p.o., dissolve in water
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Result:Reduced the number of skin tumors and inhibited tumor growth.
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Animal Model:KK.Cg-Ay/J mice[4]
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Dosage:18 mM
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Administration:p.o., in drinking water
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Result:Performed better in a glucose tolerance test. Decreased their average fasting levels of glucose and triglyceride levels in both the liver and blood serum.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 6284-40-8
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Appearance Solid
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Molecular Weight 195.21
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Formula C7H17NO5
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Color White to off-white
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SMILES
O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC
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Synonyms
Methylglucamine; Meglumin; Methylglucamin
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
H2O : 50 mg/mL (256.13 mM; Need ultrasonic)
DMSO : 10 mg/mL (51.23 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (512.27 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (275 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. de Souza ALR, et al. Meglumine-based supra-amphiphile self-assembled in water as a skin drug delivery system: Influence of unfrozen bound water in the system bioadhesiveness. Colloids Surf B Biointerfaces. 2019 Dec 1;184:110523. [Content Brief]
[2]. Manley K, et al. Preclinical study of the long-range safety and anti-inflammatory effects of high-dose oral meglumine. J Cell Biochem. 2019 Jul;120(7):12051-12062. [Content Brief]
[4]. Bravo-Nuevo A, et al. Meglumine exerts protective effects against features of metabolic syndrome and type II diabetes. PLoS One. 2014 Feb 27;9(2):e90031. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 5.1227 mL | 25.6134 mL | 51.2269 mL | 128.0672 mL |
| 5 mM | 1.0245 mL | 5.1227 mL | 10.2454 mL | 25.6134 mL | |
| 10 mM | 0.5123 mL | 2.5613 mL | 5.1227 mL | 12.8067 mL | |
| 15 mM | 0.3415 mL | 1.7076 mL | 3.4151 mL | 8.5378 mL | |
| 20 mM | 0.2561 mL | 1.2807 mL | 2.5613 mL | 6.4034 mL | |
| 25 mM | 0.2049 mL | 1.0245 mL | 2.0491 mL | 5.1227 mL | |
| 30 mM | 0.1708 mL | 0.8538 mL | 1.7076 mL | 4.2689 mL | |
| 40 mM | 0.1281 mL | 0.6403 mL | 1.2807 mL | 3.2017 mL | |
| 50 mM | 0.1025 mL | 0.5123 mL | 1.0245 mL | 2.5613 mL | |
| H2O | 60 mM | 0.0854 mL | 0.4269 mL | 0.8538 mL | 2.1345 mL |
| 80 mM | 0.0640 mL | 0.3202 mL | 0.6403 mL | 1.6008 mL | |
| 100 mM | 0.0512 mL | 0.2561 mL | 0.5123 mL | 1.2807 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Meglumine Related Classifications
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