Meglumine (GMP Like)
Meglumine (GMP Like) (Methylglucamine (GMP Like)) is the GMP Like class Meglumine (HY-B0342) that can be used as pharmaceutical excipients. Meglumine (Methylglucamine) is an orally active amino sugar derived from sorbitol. Meglumine has anti-inflammatory and antitumor activity. Meglumine is often used as an excipient in active molecules and with iodinated compounds in contrast agents such as meglumine and meglumine iodide.
For research use only. We do not sell to patients.
- CAS No.: 6284-40-8
- Formula: C7H17NO5
- Molecular Weight:195.21
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | IC50 |
>2.0 × 105M
Compound: COVC-3899212997
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Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
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10.6019/CHEMBL4651402 |
Meglumine (GMP Like) (40 or 80 mM, 24 h; 50 mM, 24 h) dose-dependently reduces the levels of inflammatory factors in THP-1 human myeloid cells and RAW264.7 mouse macrophage cells (Elisa assay)[2].
Meglumine (GMP Like) (0-300 mM, 60 min) dose-dependently increases SNARK expression levels in C2C12 mouse myoblasts[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:C2C12 mouse myoblasts
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Concentration:0, 10, 30, 100, 300 mM or 200 mM
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Incubation Time:60 min or 0, 10, 30, 60, 120 min
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Result:Increased the levels of SNARK protein in a dose-dependent manner after 60 min and reached a plateau at 30 minutes.
Meglumine (GMP Like) (18 mM, oral gavage) improves muscle function, limits metabolic syndrome, and reduces diabetic complications in type 2 diabetic mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rat[2]
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Dosage:25 or 50 mM
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Administration:p.o., dissolve in water
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Result:Reduced the isoprostane levels in rats.
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Animal Model:K6/ODC transgenic mice[2]
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Dosage:37.5 mM
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Administration:p.o., dissolve in water
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Result:Reduced the number of skin tumors and inhibited tumor growth.
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Animal Model:KK.Cg-Ay/J mice[4]
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Dosage:18 mM
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Administration:p.o., dissolve in water
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Result:Performed better in a glucose tolerance test. Decreased their average fasting levels of glucose and triglyceride levels in both the liver and blood serum.
Chemical Information
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CAS No. 6284-40-8
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Molecular Weight 195.21
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Formula C7H17NO5
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SMILES
O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC
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Synonyms
Methylglucamine (GMP Like); Meglumin (GMP Like); Methylglucamin (GMP Like)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. de Souza ALR, et al. Meglumine-based supra-amphiphile self-assembled in water as a skin drug delivery system: Influence of unfrozen bound water in the system bioadhesiveness. Colloids Surf B Biointerfaces. 2019 Dec 1;184:110523. [Content Brief]
[2]. Manley K, et al. Preclinical study of the long-range safety and anti-inflammatory effects of high-dose oral meglumine. J Cell Biochem. 2019 Jul;120(7):12051-12062. [Content Brief]
[4]. Bravo-Nuevo A, et al. Meglumine exerts protective effects against features of metabolic syndrome and type II diabetes. PLoS One. 2014 Feb 27;9(2):e90031. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Meglumine (GMP Like) Related Classifications
HY-B0342GL Related Classifications
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