2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. SRTCX1002

SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC50s of 0.71 and 7.58 µM, respectively.

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SRTCX1002 Chemical Structure

SRTCX1002 Chemical Structure

CAS No. : 1203479-63-3

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Description

SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC50s of 0.71 and 7.58 µM, respectively[1].

Molecular Weight

405.47

Formula

C21H19N5O2S
CAS No.
SMILES

O=C(NC1=NC=CS1)C2=C3NC(C4=CC=CC(N5CCOCC5)=C4)=NC3=CC=C2
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SRTCX1002 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRTCX10021203479-63-3SRTCX 1002SRTCX-1002SirtuinSIRT1 activatorSTACinflammatory responsesp65 deacetylationNF-κB ActivityInhibitorinhibitorinhibit

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