1. Immunology/Inflammation
  2. COX
  3. Imrecoxib

Imrecoxib (Synonyms: BAP-909)

Cat. No.: HY-114200 Purity: >99.0%
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Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect.

For research use only. We do not sell to patients.

Imrecoxib Chemical Structure

Imrecoxib Chemical Structure

CAS No. : 395683-14-4

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Description

Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect[1].

IC50 & Target[1]

Human COX-1

115 nM (IC50)

Human COX-2

18 nM (IC50)

In Vitro

Imrecoxib (BAP-909) (0.1-10 µM; 24 hours) decreases COX-2 mRNA level induced by PMA+LPS at a dose dependent manner in U937 cells[1].

RT-PCR[1]

Cell Line: U937 cells
Concentration: 0.1 µM; 1 µM; 10 µM
Incubation Time: 24 hours
Result: Decreased COX-2 mRNA level.
In Vivo

Imrecoxib (BAP-909) (gastrointestinal administration; 5-20 mg/kg; 1 hour before carrageenan injection) inhibits carrageenan-induced acute inflammation, and the inhibitory effect is maximal at 4 hours[1].
Imrecoxib (BAP-909) (gastrointestinal administration; 5-20 mg/kg; started on day 7; 26 days) diminishes the secondary paw swelling and inhibits heat-inactivated BCG induced-inflammtory polyarthritis[1].

Animal Model: Rat carrageenan-induced edema model[1]
Dosage: 5 mg/kg, 10 mg/kg, 20 mg/kg
Administration: Gastrointestinal administration; 5-20 mg/kg; 1 hour before carrageenan injection
Result: Inhibited the edema response with different doses.
Animal Model: Rat adjuvant-induced arthritis (AIA) model[1]
Dosage: 5 mg/kg, 10 mg/kg, 20 mg/kg
Administration: Gastrointestinal administration; 5-20 mg/kg; started on day 7; 26 days
Result: Inhibited adjuvant-induced chronic inflammation at the doses of 10 and 20 mg/kg.
Molecular Weight

369.48

Formula

C₂₁H₂₃NO₃S

CAS No.

395683-14-4

SMILES

O=C1N(CCC)CC(C2=CC=C(S(=O)(C)=O)C=C2)=C1C3=CC=C(C)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References

Purity: >99.0%

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