Cat. No.: HY-N8593

Undecane

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Based on 1 Customer Validation

Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8). Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis.

For research use only. We do not sell to patients.

Purity: 99.66%
CAS No.: 1120-21-4
Formula: C₁₁H₂₄
Molecular Weight:156.31

Storage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Undecane Chemical Structure

CAS No.: 1120-21-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

p38

NF-κB

PKA

IL-8

IL-10

All NF-κB Isoforms :

All PKA Isoforms :

All TNF Receptor Isoforms :

All Histamine Receptor Isoforms :

All p38 MAPK Isoforms :

All Interleukin Related Isoforms :

In Vitro

Undecane (1-100 µM, 24 h) has no effect on cell viability in RBL-2H3 cells and haCaT cells^[1].
Undecane (0.5-5 µM, 6 h) suppresses degranulation of sensitized RBL-2H3 cells and TNF-α release by inhibiting cAMP^[1].
Undecane (1-10 µM, 2-25 h) regulates cAMP-mediated inflammatory signaling pathway and reduces the mRNA expression of inflammatory cytokines in HaCaT cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1120-21-4
Appearance Liquid (Density: 0.7402 g/cm³)
Molecular Weight 156.31
Formula C₁₁H₂₄
Color Colorless to off-white
SMILES

CCCCCCCCCCC
Structure Classification
- Others
Initial Source
- Microorganisms
cold-adapted bacteria
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (639.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.3975 mL

31.9877 mL

63.9754 mL

5 mM

1.2795 mL

6.3975 mL

12.7951 mL

10 mM

0.6398 mL

3.1988 mL

6.3975 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 3.33 mg/mL (21.30 mM); Clear solution

This protocol yields a clear solution of ≥ 3.33 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (33.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 3.33 mg/mL (21.30 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 3.33 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (33.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 3.33 mg/mL (21.30 mM); Clear solution

This protocol yields a clear solution of ≥ 3.33 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (33.3 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (630 KB)
- English - EN (630 KB)
- Français - FR (630 KB)
- Deutsch - DE (630 KB)
- Norwegian - NO (630 KB)
- Español - ES (630 KB)
- Swedish - SV (630 KB)
- Italian - IT (630 KB)
- Portuguese - PT (630 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Choi D, Kang W, Park T. Anti-Allergic and Anti-Inflammatory Effects of Undecane on Mast Cells and Keratinocytes. Molecules. 2020;25(7):1554. Published 2020 Mar 28. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.3975 mL	31.9877 mL	63.9754 mL	159.9386 mL
	5 mM	1.2795 mL	6.3975 mL	12.7951 mL	31.9877 mL
	10 mM	0.6398 mL	3.1988 mL	6.3975 mL	15.9939 mL
	15 mM	0.4265 mL	2.1325 mL	4.2650 mL	10.6626 mL
	20 mM	0.3199 mL	1.5994 mL	3.1988 mL	7.9969 mL
	25 mM	0.2559 mL	1.2795 mL	2.5590 mL	6.3975 mL
	30 mM	0.2133 mL	1.0663 mL	2.1325 mL	5.3313 mL
	40 mM	0.1599 mL	0.7997 mL	1.5994 mL	3.9985 mL
	50 mM	0.1280 mL	0.6398 mL	1.2795 mL	3.1988 mL
	60 mM	0.1066 mL	0.5331 mL	1.0663 mL	2.6656 mL
	80 mM	0.0800 mL	0.3998 mL	0.7997 mL	1.9992 mL
	100 mM	0.0640 mL	0.3199 mL	0.6398 mL	1.5994 mL

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Undecane

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