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  2. Isolongifolene

Isolongifolene (Synonyms: (-)-Isolongifolene)

Cat. No.: HY-N7363
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Isolongifolene ((-)-Isolongifolene) is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways. Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties.

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Isolongifolene Chemical Structure

Isolongifolene Chemical Structure

CAS No. : 1135-66-6

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Description

Isolongifolene ((-)-Isolongifolene) is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways. Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties[1].

In Vitro

Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner[1].
Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells[1].
Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene[1].

Cell Viability Assay[1]

Cell Line: SH-SY5Y neuroblastoma cells
Concentration: 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 µM
Incubation Time: 26 hours
Result: Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells.

Apoptosis Analysis[1]

Cell Line: SH-SY5Y neuroblastoma cells
Concentration: 10 µM
Incubation Time: 26 hours
Result: Attenuated Rotenone-induced apoptosis in SH-SY5Y cells.

Western Blot Analysis[1]

Cell Line: SH-SY5Y neuroblastoma cells
Concentration: 10 µM
Incubation Time: 26 hours
Result: Attenuated rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.
Molecular Weight

204.35

Formula

C₁₅H₂₄

CAS No.

1135-66-6

SMILES

CC1(C)[[email protected]]23CC[[email protected]](C3)([H])C(C)(C)C2=CCC1

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Keywords:

Isolongifolene(-)-IsolongifoleneOthersTricyclicsesquiterpeneRotenonecytotoxicityROSmitochondrialdysfunctionantioxidantanti-inflammatoryanticancerInhibitorinhibitorinhibit

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