Izilendustat hydrochloride
Izilendustat hydrochloride is a potent prolyl hydroxylase inhibitor. Izilendustat hydrochloride competitively inhibits HIFPH2 activity, blocks HIF-1α degradation, stabilizes HIF-1α and HIF-2α proteins, and upregulates downstream target gene expression. Izilendustat hydrochloride can reduce intestinal inflammation and damage, enhance the ability of phagocytes to clear pathogens, and improve ischemia-related pathological phenotypes. Izilendustat hydrochloride can be used for the research of inflammatory bowel disease, ischemic vascular disease and anemia.
For research use only. We do not sell to patients.
- CAS No.: 1303513-80-5
- Formula: C22H29Cl2N3O4
- Molecular Weight:470.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
prolyl hydroxylase[1]
Izilendustat (Compound A41) (1.2 μM) hydrochloride inhibits HIFPH2 (EGLN1) activity in enzymatic assays[1].
Izilendustat (Compound A41) (1-50 μM; 7 h) hydrochloride upregulates PGK and VEGF expression in wild-type MEFs but not in HIF-1α knockout MEFs[2].
Izilendustat (10 μM) hydrochloride enhances bacterial clearance in U937 cells infected with S. aureus (Newman or MRSA strain)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Izilendustat (5-10 mg/kg; s.c.; every other day) hydrochloride enhances the antitumor effect of 5-Fluorouracil (HY-90006) in mouse colon 26 carcinoma xenograft models[1].
Izilendustat (Compound A41) (0.5-10 mg/kg; p.o./s.c.; once daily) hydrochloride reduces skin lesion size and bacterial load in S. aureus- and S. pyogenes-infected mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1303513-80-5
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Molecular Weight 470.39
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Formula C22H29Cl2N3O4
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SMILES
O=C(N1CCN(CC(C=CN2CC3=CC=C(Cl)C=C3)=C(O)C2=O)CC1)OC(C)(C)C.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Izilendustat hydrochloride Related Classifications
HY-44809A Related Classifications
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