1303513-80-5
Chemical Structure
Izilendustat hydrochloride
- CAS No.: 1303513-80-5
- Formula:C22H29Cl2N3O4
- Molecular Weight:470.39
IUPAC Name: (2R,3R,4R,5S)-1-(2-hydroxyethyl-1,1,2,2-d4)-2-(hydroxymethyl)piperidine-3,4,5-triol
InChIKey: ZDGXMSCMXBTSPU-UHFFFAOYSA-N
SMILES: O=C(N1CCN(CC(C=CN2CC3=CC=C(Cl)C=C3)=C(O)C2=O)CC1)OC(C)(C)C.[H]Cl
Biological Activity: Izilendustat hydrochloride is a potent prolyl hydroxylase inhibitor. Izilendustat hydrochloride competitively inhibits HIFPH2 activity, blocks HIF-1α degradation, stabilizes HIF-1α and HIF-2α proteins, and upregulates downstream target gene expression. Izilendustat hydrochloride can reduce intestinal inflammation and damage, enhance the ability of phagocytes to clear pathogens, and improve ischemia-related pathological phenotypes. Izilendustat hydrochloride can be used for the research of inflammatory bowel disease, ischemic vascular disease and anemia[1][2].
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Izilendustat hydrochloride | Izilendustat hydrochloride is a potent prolyl hydroxylase inhibitor. Izilendustat hydrochloride competitively inhibits HIFPH2 activity, blocks HIF-1α degradation, stabilizes HIF-1α and HIF-2α proteins, and upregulates downstream target gene expression. Izilendustat hydrochloride can reduce intestinal inflammation and damage, enhance the ability of phagocytes to clear pathogens, and improve ischemia-related pathological phenotypes. Izilendustat hydrochloride can be used for the research of inflammatory bowel disease, ischemic vascular disease and anemia. | |||||||||||||||||||||
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Keywords
