2. NF-κB
  3. NF-κB
  4. Anti-inflammatory agent 51

Anti-inflammatory agent 51 (compound 11d) is an amide/sulfonamide derivative with anti-inflammatory activities. Anti-inflammatory agent 51 inhibits NF-κB activation, has the potential for acute lung injury and ulcerative colitis research.

For research use only. We do not sell to patients.

Anti-inflammatory agent 51 Chemical Structure

Anti-inflammatory agent 51 Chemical Structure

CAS No. : 2911610-03-0

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5 mg USD 80 In-stock
10 mg USD 130 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Anti-inflammatory agent 51 (compound 11d) is an amide/sulfonamide derivative with anti-inflammatory activities. Anti-inflammatory agent 51 inhibits NF-κB activation, has the potential for acute lung injury and ulcerative colitis research[1].

In Vitro

Anti-inflammatory agent 51 (compound 11d) potently reduces the release of IL-6 ( IC50 value of 0.61 μM) and TNF-α (IC50 of 4.34 μM) , and decreased the mRNA level of cytokines in J774A.1 cells. Anti-inflammatory agent 51 restores IκBα and inhibits the translocation of phosphorylated p65 into the nucleus[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 51 Related Antibodies
In Vivo

Anti-inflammatory agent 51 (compound 11d) improved LPS-induced acute lung injury (ALI) and alleviated DSS-induced ulcerative colitis in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

498.51

Formula

C22H22N6O6S
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=S(NCC1=CC=CC=N1)(C2=CC=C(C([N+]([O-])=O)=C2)N3CCN(CC3)C4=CC=C(C=C4)[N+]([O-])=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (250.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0060 mL 10.0299 mL 20.0598 mL
5 mM 0.4012 mL 2.0060 mL 4.0120 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0060 mL 10.0299 mL 20.0598 mL 50.1494 mL
5 mM 0.4012 mL 2.0060 mL 4.0120 mL 10.0299 mL
10 mM 0.2006 mL 1.0030 mL 2.0060 mL 5.0149 mL
15 mM 0.1337 mL 0.6687 mL 1.3373 mL 3.3433 mL
20 mM 0.1003 mL 0.5015 mL 1.0030 mL 2.5075 mL
25 mM 0.0802 mL 0.4012 mL 0.8024 mL 2.0060 mL
30 mM 0.0669 mL 0.3343 mL 0.6687 mL 1.6716 mL
40 mM 0.0501 mL 0.2507 mL 0.5015 mL 1.2537 mL
50 mM 0.0401 mL 0.2006 mL 0.4012 mL 1.0030 mL
60 mM 0.0334 mL 0.1672 mL 0.3343 mL 0.8358 mL
80 mM 0.0251 mL 0.1254 mL 0.2507 mL 0.6269 mL
100 mM 0.0201 mL 0.1003 mL 0.2006 mL 0.5015 mL
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Anti-inflammatory agent 51 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 512911610-03-0NF-κBNuclear factor-κBNuclear factor-kappaBAnti-inflammatory agentacute lung injuryulcerative colitisIL-6TNF-αInhibitorinhibitorinhibit

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