Anti-inflammatory agent 51
Based on 1 Customer Validation
Anti-inflammatory agent 51 (compound 11d) is an amide/sulfonamide derivative with anti-inflammatory activities. Anti-inflammatory agent 51 inhibits NF-κB activation, has the potential for acute lung injury and ulcerative colitis research.
For research use only. We do not sell to patients.
- Purity: 98.08%
- CAS No.: 2911610-03-0
- Formula: C22H22N6O6S
- Molecular Weight:498.51
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774.A1 | IC50 |
0.61 μM
Compound: 11d
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Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-induced IL-6 release preincubated with compound for 30 mins followed by LPS-induction and measured after 24 hrs by ELISA analysis
Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-induced IL-6 release preincubated with compound for 30 mins followed by LPS-induction and measured after 24 hrs by ELISA analysis
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[PMID: 37572538] |
| J774.A1 | IC50 |
4.34 μM
Compound: 11d
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Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-induced TNF-alpha release preincubated with compound for 30 mins followed by LPS-induction and measured after 24 hrs by ELISA analysis
Antiinflammatory activity against mouse J774.A1 cells assessed as inhibition of LPS-induced TNF-alpha release preincubated with compound for 30 mins followed by LPS-induction and measured after 24 hrs by ELISA analysis
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[PMID: 37572538] |
Anti-inflammatory agent 51 (compound 11d) potently reduces the release of IL-6 ( IC50 value of 0.61 μM) and TNF-α (IC50 of 4.34 μM) , and decreased the mRNA level of cytokines in J774A.1 cells. Anti-inflammatory agent 51 restores IκBα and inhibits the translocation of phosphorylated p65 into the nucleus[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2911610-03-0
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Appearance Solid
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Molecular Weight 498.51
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Formula C22H22N6O6S
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Color Yellow to orange
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SMILES
O=S(NCC1=CC=CC=N1)(C2=CC=C(C([N+]([O-])=O)=C2)N3CCN(CC3)C4=CC=C(C=C4)[N+]([O-])=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (250.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0060 mL | 10.0299 mL | 20.0598 mL | 50.1494 mL |
| 5 mM | 0.4012 mL | 2.0060 mL | 4.0120 mL | 10.0299 mL | |
| 10 mM | 0.2006 mL | 1.0030 mL | 2.0060 mL | 5.0149 mL | |
| 15 mM | 0.1337 mL | 0.6687 mL | 1.3373 mL | 3.3433 mL | |
| 20 mM | 0.1003 mL | 0.5015 mL | 1.0030 mL | 2.5075 mL | |
| 25 mM | 0.0802 mL | 0.4012 mL | 0.8024 mL | 2.0060 mL | |
| 30 mM | 0.0669 mL | 0.3343 mL | 0.6687 mL | 1.6716 mL | |
| 40 mM | 0.0501 mL | 0.2507 mL | 0.5015 mL | 1.2537 mL | |
| 50 mM | 0.0401 mL | 0.2006 mL | 0.4012 mL | 1.0030 mL | |
| 60 mM | 0.0334 mL | 0.1672 mL | 0.3343 mL | 0.8358 mL | |
| 80 mM | 0.0251 mL | 0.1254 mL | 0.2507 mL | 0.6269 mL | |
| 100 mM | 0.0201 mL | 0.1003 mL | 0.2006 mL | 0.5015 mL |
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