1. Immunology/Inflammation
    Apoptosis
  2. COX
    Apoptosis
  3. ATB-346

ATB-346 

Cat. No.: HY-15028 Purity: 98.35%
Handling Instructions

ATB-346 an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2) ATB-346 possesses antiinflammatory and antinociceptive activities.

For research use only. We do not sell to patients.

ATB-346 Chemical Structure

ATB-346 Chemical Structure

CAS No. : 1226895-20-0

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 187 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Estimated Time of Arrival: December 31
50 mg USD 638 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1020 In-stock
Estimated Time of Arrival: December 31
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Description

ATB-346 an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2) ATB-346 possesses antiinflammatory and antinociceptive activities[1][4].

IC50 & Target[1]

COX-1

 

COX-2

 

In Vitro

ATB-346 (100 μM) inhibits human melanoma cell proliferation by inhibiting pro-survival pathways associated with NF-B and Akt activation[2].
ATB-346 (100 μM) induces apoptosis of human melanoma cells[2].
ATB-346 (100 M) causes inhibition of IkB degradation and of NF-kB nuclear translocation as demonstrated by a reduction in band intensity of the p65 subunit in A375 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: A375 cells.
Concentration: 100 μM.
Incubation Time: 24, 48 and 72 h.
Result: Caused an inhibition of cell proliferation by 38.2%, 63.2% and 66%, respectively (P < 0.001).
In Vivo

ATB-346 exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity[1].
ATB-346 (orally, 43 μmol/kg) inhibits growth of melanoma tumors in vivo and reduce plasma levels of melanoma-associated chemokines[2].
ATB-346 (orally, 16 mg/kg) results in significant inhibition of bone defect and other histological characteristics (such as flatness of the gingival epithelium, chronic inflammatory cell infiltration and loss of connective tissue in the gingival papillae). ATB-346 inhibits the increase of gingival IL-1β and IL-6 secondary to periodontitis, but IL-10 is unaffected[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male, Wistar rats (200-225 g)[1].
Dosage: 30, 60, 120 and 2740 μmol/kg.
Administration: Orally once.
Result: Inhibited PGE2 levels.
Suppressed TXB2 synthesis.
Animal Model: Male, Wistar rats (200-225 g)[1].
Dosage: 4 μmol/kg.
Administration: Orally twice daily, on days 7 to 21.
Result: Significantly reduced paw oedema at days 14 and 21 (*P < 0.05 vs. the vehicle-treated group).
Caused markedly less gastric damage at all doses tested than naproxen.
Clinical Trial
Molecular Weight

365.45

Formula

C₂₁H₁₉NO₃S

CAS No.
SMILES

COC1=CC=C(C=C(C(C)C(OC2=CC=C(C(N)=S)C=C2)=O)C=C3)C3=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 51.6 mg/mL (141.20 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7364 mL 13.6818 mL 27.3635 mL
5 mM 0.5473 mL 2.7364 mL 5.4727 mL
10 mM 0.2736 mL 1.3682 mL 2.7364 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.84 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.35%

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Keywords:

ATB-346ATB346ATB 346COXApoptosisCyclooxygenaseColorectalcancerPGE2TXB2melanomaperiodontitisbonelossInhibitorinhibitorinhibit

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ATB-346
Cat. No.:
HY-15028
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