1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. BML-111

BML-111 

Cat. No.: HY-100450
Handling Instructions

BML-111, a lipoxin A4 analog, is a lipoxin A4 receptor agonist. BML-111 represses the activity of angiotensin converting enzyme (ACE) and increases the activity of angiotensinconverting enzyme 2 (ACE2). BML-111 has antiangiogenic, antitumor and anti-inflammatory properties.

For research use only. We do not sell to patients.

BML-111 Chemical Structure

BML-111 Chemical Structure

CAS No. : 78606-80-1

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Description

BML-111, a lipoxin A4 analog, is a lipoxin A4 receptor agonist. BML-111 represses the activity of angiotensin converting enzyme (ACE) and increases the activity of angiotensinconverting enzyme 2 (ACE2). BML-111 has antiangiogenic, antitumor and anti-inflammatory properties[1][2].

IC50 & Target

Lipoxin A4 receptor[1]
Angiotensin converting enzyme (ACE)[2]

In Vitro

In H22 cells, BML-111 inhibits the production of vascular endothelial growth factor and reduces hypoxia-inducible factor-1α level[1].
BML-111 inhibits leukotriene B4-induced cellular migration with an IC50 of 5 nM[3].

In Vivo

BML-111 (1 mg/kg; intraperitoneal injection; for 15 days; male Imprinting Control Region mice) treatment suppresses tumor-related angiogenesis and tumor growth in vivo. BML-111 also enhances the in situ apoptosis while inhibiting macrophage infiltration in tumor tissue[1].
BML-111 protects LPS-induced acute lung injury and LPS/D-GalN-induced acute liver injury. BML-111 represses the activity of ACE, but increases the activity of ACE2. BML-111 decreases the expression levels of ACE, AngII, and AngII type 1 receptor (AT1R), meanwhile increases the levels of ACE2, angiotensin-(1-7) (Ang-1-7), and Mas[2].

Animal Model: Male Imprinting Control Region mice (5-6-week-old,18-22 g) injected with H22 cells[1]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection; injected 5 minutes before and 4 hours after H22 cell inoculation, then every 12 hours for 2 consecutive days, then daily in an additional 3 days and every other day for the last 10 days
Result: Suppressed tumor-related angiogenesis and tumor growth in vivo.
Molecular Weight

192.21

Formula

C₈H₁₆O₅

CAS No.

78606-80-1

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BML-111BML111BML 111Angiotensin-converting Enzyme (ACE)RAASlipoxinantiangiogenicantitumoranti-inflammatoryhepaticfibrosisHIF-1αLTB4Inhibitorinhibitorinhibit

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BML-111
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HY-100450
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