2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. BML-111

BML-111 

Cat. No.: HY-100450 Purity: ≥98.0%
COA Handling Instructions

BML-111, a lipoxin A4 analog, is a lipoxin A4 receptor agonist. BML-111 represses the activity of angiotensin converting enzyme (ACE) and increases the activity of angiotensinconverting enzyme 2 (ACE2). BML-111 has antiangiogenic, antitumor and anti-inflammatory properties.

For research use only. We do not sell to patients.

BML-111 Chemical Structure

BML-111 Chemical Structure

CAS No. : 78606-80-1

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5 mg USD 680 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

BML-111, a lipoxin A4 analog, is a lipoxin A4 receptor agonist. BML-111 represses the activity of angiotensin converting enzyme (ACE) and increases the activity of angiotensinconverting enzyme 2 (ACE2). BML-111 has antiangiogenic, antitumor and anti-inflammatory properties[1][2].

IC50 & Target

Lipoxin A4 receptor[1]
Angiotensin converting enzyme (ACE)[2]
In Vitro

In H22 cells, BML-111 inhibits the production of vascular endothelial growth factor and reduces hypoxia-inducible factor-1α level[1].
BML-111 inhibits leukotriene B4-induced cellular migration with an IC50 of 5 nM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

BML-111 (1 mg/kg; intraperitoneal injection; for 15 days; male Imprinting Control Region mice) treatment suppresses tumor-related angiogenesis and tumor growth in vivo. BML-111 also enhances the in situ apoptosis while inhibiting macrophage infiltration in tumor tissue[1].
BML-111 protects LPS-induced acute lung injury and LPS/D-GalN-induced acute liver injury. BML-111 represses the activity of ACE, but increases the activity of ACE2. BML-111 decreases the expression levels of ACE, AngII, and AngII type 1 receptor (AT1R), meanwhile increases the levels of ACE2, angiotensin-(1-7) (Ang-1-7), and Mas[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Imprinting Control Region mice (5-6-week-old,18-22 g) injected with H22 cells[1]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection; injected 5 minutes before and 4 hours after H22 cell inoculation, then every 12 hours for 2 consecutive days, then daily in an additional 3 days and every other day for the last 10 days
Result: Suppressed tumor-related angiogenesis and tumor growth in vivo.
Molecular Weight

192.21

Appearance

Solid-liquid mixture

Formula

C8H16O5
CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (520.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2026 mL 26.0132 mL 52.0264 mL
5 mM 1.0405 mL 5.2026 mL 10.4053 mL
10 mM 0.5203 mL 2.6013 mL 5.2026 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (13.01 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (13.01 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (13.01 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

COA (243 KB) HNMR (462 KB) LCMS (78 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

BML-11178606-80-1BML111BML 111Angiotensin-converting Enzyme (ACE)RAASlipoxinantiangiogenicantitumoranti-inflammatoryhepaticfibrosisHIF-1αLTB4Inhibitorinhibitorinhibit

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