1. NF-κB MAPK/ERK Pathway
  2. NF-κB p38 MAPK
  3. 12-Oxo phytodienoic acid

12-Oxo phytodienoic acid (12-OPDA) is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid suppresses neuroinflammation by inhibiting Nf-κB and p38 MAPK signaling in LPS-activated cells. 12-Oxo phytodienoic acid can be used for neurodegenerative diseases research.

For research use only. We do not sell to patients.

12-Oxo phytodienoic acid Chemical Structure

12-Oxo phytodienoic acid Chemical Structure

CAS No. : 85551-10-6

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1mg (3.42 mM * 1 mL in Ethanol) USD 535 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

12-Oxo phytodienoic acid (12-OPDA) is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid suppresses neuroinflammation by inhibiting Nf-κB and p38 MAPK signaling in LPS-activated cells. 12-Oxo phytodienoic acid can be used for neurodegenerative diseases research[1].

In Vitro

12-Oxo phytodienoic acid (12-OPDA) (7.5, 15, 30 μM, 6, 24 h) protects MG5 cells against inflammation induced by LPS[1].
12-Oxo phytodienoic acid (12-OPDA) (7.5, 15, 30 μM, 6, 24 h) suppresses LPS-induced activation of NF-κB and p38 MAPK and induces SOCS-1 transcription in MG5 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR[1]

Cell Line: MG5 cells
Concentration: 7.5, 15, 30 μM
Incubation Time: 6, 24 h
Result: Reduced LPS-induced mRNA expression of IL-6, TNF-α, and iNOS in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: MG5 cells
Concentration: 7.5, 15, 30 μM
Incubation Time: 6, 24 h
Result: Decreased the protein levels of IL-6 and TNF-α and NO level.
Reduced LPS-induced phosphorylation of p38, but had no effect on phosphorylation of JNK.
Elevated expression of HO-1 protein.
Molecular Weight

292.41

Formula

C18H28O3

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)CCCCCCC[C@H]1C=CC([C@H]1C/C=C\CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Purity & Documentation

Purity: 99.50%

References
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12-Oxo phytodienoic acid Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
12-Oxo phytodienoic acid
Cat. No.:
HY-118828
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