12-Oxo phytodienoic acid
Based on 1 publication(s) in Google Scholar
12-Oxo phytodienoic acid (12-OPDA) is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid suppresses neuroinflammation by inhibiting Nf-κB and p38 MAPK signaling in Lipopolysaccharides (LPS) (HY-D1056)-activated cells. 12-Oxo phytodienoic acid can be used for neurodegenerative diseases research.
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- CAS. Nr.: 85551-10-6
- Formel: C18H28O3
- Molecular Weight:292.41
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Speicherung:
Solution, -20°C, 2 years
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Biologische Aktivität
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Publications Citing Use of MedChemExpress (MCE) 12-Oxo phytodienoic acid
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Biologische Aktivität
Beschreibung
In Vitro
12-Oxo phytodienoic acid (12-OPDA) (7.5, 15, 30 μM, 6, 24 h) protects MG5 cells against inflammation induced by LPS[1].
12-Oxo phytodienoic acid (12-OPDA) (7.5, 15, 30 μM, 6, 24 h) suppresses LPS-induced activation of NF-κB and p38 MAPK and induces SOCS-1 transcription in MG5 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MG5 cells
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Concentration:7.5, 15, 30 μM
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Incubation Time:6, 24 h
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Result:Reduced LPS-induced mRNA expression of IL-6, TNF-α, and iNOS in a concentration-dependent manner.
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Cell Line:MG5 cells
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Concentration:7.5, 15, 30 μM
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Incubation Time:6, 24 h
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Result:Decreased the protein levels of IL-6 and TNF-α and NO level.
Reduced LPS-induced phosphorylation of p38, but had no effect on phosphorylation of JNK.
Elevated expression of HO-1 protein.
Chemical Information
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CAS. Nr. 85551-10-6
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Appearance Liquid
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Molecular Weight 292.41
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Formel C18H28O3
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Color Colorless to light yellow
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SMILES
O=C(O)CCCCCCC[C@H]1C=CC([C@H]1C/C=C\CC)=O
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Synonyms
12-OPDA
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Solution, -20°C, 2 years
Publications (1)
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Journal Impact Factor
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Most Recent
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Molecules
Untargeted Metabolomics Using UHPLC-HRMS Reveals Metabolic Changes of Fresh-Cut Potato during Browning Process. [Abstract]2023 Apr 11;28(8):3375. PMID: 37110608
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Data Sheet (270 KB)
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- Italian - IT (419 KB)
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Handling Instructions (2659 KB)
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
12-Oxo phytodienoic acid Related Classifications
HY-118828 Related Classifications
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