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Cat. No.: HY-118828

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12-Oxo phytodienoic acid

(Synonyms: 12-OPDA)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

12-Oxo phytodienoic acid (12-OPDA) is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid suppresses neuroinflammation by inhibiting Nf-κB and p38 MAPK signaling in Lipopolysaccharides (LPS) (HY-D1056)-activated cells. 12-Oxo phytodienoic acid can be used for neurodegenerative diseases research.

For research use only. We do not sell to patients.

CAS No.: 85551-10-6
Formula: C₁₈H₂₈O₃
Molecular Weight:292.41

Storage:

Solution, -20°C, 2 years

12-Oxo phytodienoic acid Chemical Structure

CAS No.: 85551-10-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
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Bioz

Biological Activity

Description

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

All NO Synthase Isoforms :

All p38 MAPK Isoforms :

All NF-κB Isoforms :

In Vitro

12-Oxo phytodienoic acid (12-OPDA) (7.5, 15, 30 μM, 6, 24 h) protects MG5 cells against inflammation induced by LPS^[1].
12-Oxo phytodienoic acid (12-OPDA) (7.5, 15, 30 μM, 6, 24 h) suppresses LPS-induced activation of NF-κB and p38 MAPK and induces SOCS-1 transcription in MG5 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

MG5 cells
Concentration:

7.5, 15, 30 μM
Incubation Time:

6, 24 h
Result:

Reduced LPS-induced mRNA expression of IL-6, TNF-α, and iNOS in a concentration-dependent manner.

Western Blot Analysis^[1]

Cell Line:

MG5 cells
Concentration:

7.5, 15, 30 μM
Incubation Time:

6, 24 h
Result:

Decreased the protein levels of IL-6 and TNF-α and NO level.
Reduced LPS-induced phosphorylation of p38, but had no effect on phosphorylation of JNK.
Elevated expression of HO-1 protein.

Chemical Information

CAS No. 85551-10-6
Appearance Liquid
Molecular Weight 292.41
Formula C₁₈H₂₈O₃
Color Colorless to light yellow
SMILES

O=C(O)CCCCCCC[C@H]1C=CC([C@H]1C/C=C\CC)=O
Synonyms

12-OPDA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years

Publications (1)

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Molecules

Untargeted Metabolomics Using UHPLC-HRMS Reveals Metabolic Changes of Fresh-Cut Potato during Browning Process. [Abstract]

2023 Apr 11;28(8):3375. PMID: 37110608

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Taki-Nakano N, et al. 12-oxo-phytodienoic acid, a plant-derived oxylipin, attenuates lipopolysaccharide-induced inflammation in microglia. Biochem Biophys Res Commun. 2016;473(4):1288-1294. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

12-Oxo phytodienoic acid

1 Cited Publications

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Biological Activity
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Publications (1)
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12-Oxo phytodienoic acid

Publications Citing Use of MedChemExpress (MCE) 12-Oxo phytodienoic acid

All TNF Receptor Isoforms

All Interleukin Related Isoforms

All NO Synthase Isoforms

All p38 MAPK Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

12-Oxo phytodienoic acid Related Classifications

HY-118828 Related Classifications