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Cat. No.: HY-118828B

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12-Oxo phytodienoic acid (≥90%)

(Synonyms: 12-OPDA (≥90%))

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

12-Oxo phytodienoic acid (≥90%) (12-OPDA (≥90%)) is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid (≥90%) induces the expression of SOCS-1 and inhibits LPS (HY-D1056)-induced activation of the NF-κB and p38 MAPK signaling pathways. 12-Oxo phytodienoic acid (≥90%) inhibits LPS-induced expression of IL-6 and TNF-α, and reduces LPS-induced NO production by decreasing iNOS levels. 12-Oxo phytodienoic acid (≥90%) induces activation of the Nrf2 signaling cascade. 12-Oxo phytodienoic acid (≥90%) can be used for the research of neurodegenerative diseases.

For research use only. We do not sell to patients.

Purity: 92.2%
CAS No.: 85551-10-6
Formula: C₁₈H₂₈O₃
Molecular Weight:292.41

Storage:

Solution, -20°C, protect from light, 2 years

12-Oxo phytodienoic acid (≥90%) Chemical Structure

CAS No.: 85551-10-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References
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Bioz

Biological Activity

Description

All NF-κB Isoforms :

All p38 MAPK Isoforms :

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

All NO Synthase Isoforms :

In Vitro

12-Oxo phytodienoic acid (7.5-30 μM; 24 h) reduces LPS-induced IL-6, TNF-α and iNOS mRNA expression in a concentration-dependent manner and upregulates SOCS-1 mRNA expression in MG5 cells^[1].
12-Oxo phytodienoic acid (7.5-30 μM; 24 h pretreatment) inhibits LPS-induced production of IL-6, TNF-α and NO in MG5 cells in a concentration-dependent manner^[1].
12-Oxo phytodienoic acid (15-30 μM; 24 h pretreatment) blocks LPS-induced NF-κB pathway activation and MAPK activation in MG5 cells by inhibiting IκBα degradation and p65 phosphorylation^[1].
12-Oxo phytodienoic acid (30 μM; 6-24 h) promotes the nuclear translocation of Nrf2 and upregulates the expression of HO-1 protein in MG5 cells 48 h after transfection with negative control siRNA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

mouse microglial MG5 cells
Concentration:

7.5 μM, 15 μM, 30 μM
Incubation Time:

24 h (pretreatment); 3 h (LPS exposure)
Result:

Significantly reduced LPS-induced mRNA expression of interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), and inducible nitric oxide synthase (iNOS) in a concentration-dependent manner.

Western Blot Analysis^[1]

Cell Line:

mouse microglial MG5 cells
Concentration:

15 μM, 30 μM
Incubation Time:

24 h (pretreatment); 30 min (LPS exposure)
Result:

Suppressed LPS-induced degradation of IkBα and reduced LPS-induced phosphorylation of p65, with no effect on total p65 levels.\nReduced LPS-induced phosphorylation of p38, with no effect on phosphorylation of JNK or total levels of p38 and JNK.

Real Time qPCR^[1]

Cell Line:

mouse microglial MG5 cells
Concentration:

30 μM
Incubation Time:

24 h
Result:

Significantly elevated SOCS-1 transcript levels.

Western Blot Analysis^[1]

Cell Line:

mouse microglial MG5 cells
Concentration:

30 μM
Incubation Time:

6 h (reagent treatment); 48 h (siRNA transfection)
Result:

Increased Nrf2 protein levels in nuclear extracts of MG5 cells.

Western Blot Analysis^[1]

Cell Line:

mouse microglial MG5 cells
Concentration:

30 μM
Incubation Time:

24 h (reagent treatment); 48 h (siRNA transfection)
Result:

Elevated HO-1 protein levels in MG5 cells.

Chemical Information

CAS No. 85551-10-6
Appearance Liquid
Molecular Weight 292.41
Formula C₁₈H₂₈O₃
Color Colorless to light yellow
SMILES

O=C(O)CCCCCCC[C@H]1C=CC([C@H]1C/C=C\CC)=O
Synonyms

12-OPDA (≥90%)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, protect from light, 2 years

Publications (1)

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Molecules

Untargeted Metabolomics Using UHPLC-HRMS Reveals Metabolic Changes of Fresh-Cut Potato during Browning Process. [Abstract]

2023 Apr 11;28(8):3375. PMID: 37110608

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Taki-Nakano N, et al. 12-oxo-phytodienoic acid, a plant-derived oxylipin, attenuates lipopolysaccharide-induced inflammation in microglia. Biochem Biophys Res Commun. 2016;473(4):1288-1294. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

12-Oxo phytodienoic acid (≥90%)

1 Cited Publications

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References

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12-Oxo phytodienoic acid (≥90%)

Publications Citing Use of MedChemExpress (MCE) 12-Oxo phytodienoic acid (≥90%)

All NF-κB Isoforms

All p38 MAPK Isoforms

All TNF Receptor Isoforms

All Interleukin Related Isoforms

All NO Synthase Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

12-Oxo phytodienoic acid (≥90%) Related Classifications

HY-118828B Related Classifications