12-Oxo phytodienoic acid (≥90%)  (Synonyms: 12-OPDA (≥90%))

12-Oxo phytodienoic acid (≥90%) (12-OPDA (≥90%)) is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid (≥90%) induces the expression of SOCS-1 and inhibits LPS (HY-D1056)-induced activation of the NF-κB and p38 MAPK signaling pathways. 12-Oxo phytodienoic acid (≥90%) inhibits LPS-induced expression of IL-6 and TNF-α, and reduces LPS-induced NO production by decreasing iNOS levels. 12-Oxo phytodienoic acid (≥90%) induces activation of the Nrf2 signaling cascade. 12-Oxo phytodienoic acid (≥90%) can be used for the research of neurodegenerative diseases^[1].

12-Oxo phytodienoic acid (7.5-30 μM; 24 h) reduces LPS-induced IL-6, TNF-α and iNOS mRNA expression in a concentration-dependent manner and upregulates SOCS-1 mRNA expression in MG5 cells^[1].
12-Oxo phytodienoic acid (7.5-30 μM; 24 h pretreatment) inhibits LPS-induced production of IL-6, TNF-α and NO in MG5 cells in a concentration-dependent manner^[1].
12-Oxo phytodienoic acid (15-30 μM; 24 h pretreatment) blocks LPS-induced NF-κB pathway activation and MAPK activation in MG5 cells by inhibiting IκBα degradation and p65 phosphorylation^[1].
12-Oxo phytodienoic acid (30 μM; 6-24 h) promotes the nuclear translocation of Nrf2 and upregulates the expression of HO-1 protein in MG5 cells 48 h after transfection with negative control siRNA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

292.41

C₁₈H₂₈O₃

85551-10-6

Liquid

Colorless to light yellow

O=C(O)CCCCCCC[C@H]1C=CC([C@H]1C/C=C\CC)=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, protect from light, 2 years

• [1]. Taki-Nakano N, et al. 12-oxo-phytodienoic acid, a plant-derived oxylipin, attenuates lipopolysaccharide-induced inflammation in microglia. Biochem Biophys Res Commun. 2016;473(4):1288-1294.  [Content Brief]