1. Anti-infection
  2. Antibiotic Bacterial SARS-CoV
  3. Setomimycin

Setomimycin 

Cat. No.: HY-124439
Handling Instructions

Setomimycin is a potent antibiotic. Setomimycin inhibits the SARS-CoV-2 Mpro enzyme with an IC50 value of 12.02 µM. Setomimycin shows anti-inflammatory and antioxidant properties. Setomimycin shows antiproliferative and antitumor activity.

For research use only. We do not sell to patients.

Setomimycin Chemical Structure

Setomimycin Chemical Structure

CAS No. : 69431-87-4

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Based on 1 publication(s) in Google Scholar

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Description

Setomimycin is a potent antibiotic. Setomimycin inhibits the SARS-CoV-2 Mpro enzyme with an IC50 value of 12.02 µM. Setomimycin shows anti-inflammatory and antioxidant properties. Setomimycin shows antiproliferative and antitumor activity[1][2].

IC50 & Target

IC50: 12.02 µM (SARS-CoV-2 Mpro)[1]

In Vitro

Setomimycin (0.01-1 µM) inhibits the release of cytokines IL-1β, IL-6 and TNF-α and nitric oxide release from LPS stimulated RAW 264.7 cells in a dose-dependent manner[1].
Setomimycin (compound 1) shows antimicrobial activity with MICs of 8, 4, 16, 4 μg/mL for Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Micrococcus luteus, respectively[2].
Setomimycin (0-100 µM; 5 days) shows antiproliferative activity and inhibits colony formation[2].
Setomimycin (4, 5.5, 7 µM) decreases the protein expression of p-MEK, p-ERK, Bcl-2, increases the expression of Par-4[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: A549; HOP-92; Panc-1; MiaPaca-2 cells
Concentration: 0-100 µM
Incubation Time: 44 h
Result: Showed antiproliferative activity with IC50s of 11.45, >100, 48, 4.57 µM for A549; HOP-92; Panc-1; MiaPaca-2 cells, respectively.

Western Blot Analysis[2]

Cell Line: MCF-7, HCT-116 cells
Concentration: 4, 5.5, 7 µM
Incubation Time:
Result: Decreased the protein expression of p-MEK, p-ERK, Bcl-2, increased the expression of Par-4 in a dose-dependent manner.
In Vivo

Setomimycin (20 mg/kg; i.p.; alternate days for two weeks) shows antitumor activity in mice[2].
Pharmacokinetic Parameters of Setomimycin in female BALB/c mice[2].

Pharmacokinetic parameters Value
Cmax (ng/ml) 694 ± 62
Tmax (h) 0.3 ± 0.1
T1/2 (h) 2.3 ± 0.5
AUC0-t (ng.h/mL) 2613 ± 111
AUC0-α (ng.h/mL) 2734 ± 108
Vd (L/Kg) 24 ± 4
Cl (L/h/Kg) 7.4 ± 0.3
Female BALB/c mice, 20 mg/kg ip (1 % DMSO +30 % PEG-200 + 2 % Tween 80 + q.s. water (v/v))[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6 weeks, 25-30 g, female BALB/c mice (4T1 cells)[2]
Dosage: 20 mg/kg
Administration: I.p.; every other day for two weeks
Result: Decreased primary tumor weight (76%) and volume (90.5%).
Molecular Weight

580.58

Formula

C34H28O9

CAS No.
SMILES

O=C1CC(C)(O)C(C(C)=O)C2=C1C(O)=C3C(O)=CC=CC3=C2C4=C5C=CC=C(O)C5=C(O)C6=C4C(C(C)=O)C(C)=CC6=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Setomimycin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Setomimycin
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HY-124439
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