Setomimycin
Setomimycin is a potent antibiotic. Setomimycin inhibits the SARS-CoV-2 Mpro enzyme with an IC50 value of 12.02 µM. Setomimycin shows anti-inflammatory and antioxidant properties. Setomimycin shows antiproliferative and antitumor activity.
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- No. CAS: 69431-87-4
- Fòrmula: C34H28O9
- Peso molecular:580.58
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
IC50: 12.02 µM (SARS-CoV-2 Mpro)[1]
Setomimycin (0.01-1 µM) inhibits the release of cytokines IL-1β, IL-6 and TNF-α and nitric oxide release from LPS stimulated RAW 264.7 cells in a dose-dependent manner[1].
Setomimycin (compound 1) shows antimicrobial activity with MICs of 8, 4, 16, 4 μg/mL for Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Micrococcus luteus, respectively[2].
Setomimycin (0-100 µM; 5 days) shows antiproliferative activity and inhibits colony formation[2].
Setomimycin (4, 5.5, 7 µM) decreases the protein expression of p-MEK, p-ERK, Bcl-2, increases the expression of Par-4[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549; HOP-92; Panc-1; MiaPaca-2 cells
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Concentration:0-100 µM
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Incubation Time:44 h
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Result:Showed antiproliferative activity with IC50s of 11.45, >100, 48, 4.57 µM for A549; HOP-92; Panc-1; MiaPaca-2 cells, respectively.
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Cell Line:MCF-7, HCT-116 cells
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Concentration:4, 5.5, 7 µM
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Incubation Time:
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Result:Decreased the protein expression of p-MEK, p-ERK, Bcl-2, increased the expression of Par-4 in a dose-dependent manner.
Pharmacokinetic Parameters of Setomimycin in female BALB/c mice[2].
| Pharmacokinetic parameters | Value |
| Cmax (ng/ml) | 694 ± 62 |
| Tmax (h) | 0.3 ± 0.1 |
| T1/2 (h) | 2.3 ± 0.5 |
| AUC0-t (ng.h/mL) | 2613 ± 111 |
| AUC0-α (ng.h/mL) | 2734 ± 108 |
| Vd (L/Kg) | 24 ± 4 |
| Cl (L/h/Kg) | 7.4 ± 0.3 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6 weeks, 25-30 g, female BALB/c mice (4T1 cells)[2]
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Dosage:20 mg/kg
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Administration:I.p.; every other day for two weeks
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Result:Decreased primary tumor weight (76%) and volume (90.5%).
Chemical Information
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No. CAS 69431-87-4
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Peso molecular 580.58
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Fòrmula C34H28O9
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SMILES
O=C1CC(C)(O)C(C(C)=O)C2=C1C(O)=C3C(O)=CC=CC3=C2C4=C5C=CC=C(O)C5=C(O)C6=C4C(C(C)=O)C(C)=CC6=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Manhas RS, et al. Setomimycin as a potential molecule for COVID‑19 target: in silico approach and in vitro validation. Mol Divers. 2023 Apr;27(2):619-633. [Content Brief]
[2]. Manhas RS, et al. Isolation and anticancer activity evaluation of rare Bisaryl anthraquinone antibiotics from novel Streptomyces sp. strain of NW Himalayan region. Chem Biol Interact. 2022 Sep 25;365:110093. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Setomimycin Related Classifications
HY-124439 Related Classifications
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