9-cis-Retinoic acid-d5
Based on 1 Customer Validation
9-cis-Retinoic acid-d5 is the deuterium labeled 9-cis-Retinoic acid. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities.
For research use only. We do not sell to patients.
- Purity: 99.24%
- Formula: C20H23D5O2
- Molecular Weight:305.47
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Storage:
-80°C, protect from light, stored under nitrogen
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 5300-03-8
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Appearance Solid
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Molecular Weight 305.47
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Formula C20H23D5O2
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Color Light yellow to yellow
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SMILES
CC(/C=C/C(C(C)(CCC1([2H])[2H])C)=C1C([2H])([2H])[2H])=C/C=C/C(C)=C/C(O)=O
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light, stored under nitrogen
Solvent & Solubility
DMSO : 25 mg/mL (81.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Raul Rosas, et al. Retinoids Augment Thiazolidinedione PPARγ Activation in Oral Cancer Cells. Anticancer Res. 2020 Jun;40(6):3071-3080. [Content Brief]
[3]. Hua Yang, et al. Effects of 9-cis-retinoic Acid on the Proliferation and Apoptosis of Cutaneous T-cell Lymphoma Cells. Anticancer Drugs. 2019 Jan;30(1):56-64. [Content Brief]
[4]. Zhiqing Yuan, et al. 9-cis-retinoic Acid Elevates MRP3 Expression by Inhibiting Sumoylation of RXRα to Alleviate Cholestatic Liver Injury. Biochem Biophys Res Commun. 2018 Sep 3;503(1):188-194. [Content Brief]
[5]. V M Manzano, et al. Human Renal Mesangial Cells Are a Target for the Anti-Inflammatory Action of 9-cis Retinoic Acid. Br J Pharmacol. 2000 Dec;131(8):1673-83. [Content Brief]
[6]. Gro H Mathisen, et al. Delayed Translocation of NGFI-B/RXR in Glutamate Stimulated Neurons Allows Late Protection by 9-cis Retinoic Acid. Biochem Biophys Res Commun. 2011 Oct 14;414(1):90-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.2736 mL | 16.3682 mL | 32.7364 mL | 81.8411 mL |
| 5 mM | 0.6547 mL | 3.2736 mL | 6.5473 mL | 16.3682 mL | |
| 10 mM | 0.3274 mL | 1.6368 mL | 3.2736 mL | 8.1841 mL | |
| 15 mM | 0.2182 mL | 1.0912 mL | 2.1824 mL | 5.4561 mL | |
| 20 mM | 0.1637 mL | 0.8184 mL | 1.6368 mL | 4.0921 mL | |
| 25 mM | 0.1309 mL | 0.6547 mL | 1.3095 mL | 3.2736 mL | |
| 30 mM | 0.1091 mL | 0.5456 mL | 1.0912 mL | 2.7280 mL | |
| 40 mM | 0.0818 mL | 0.4092 mL | 0.8184 mL | 2.0460 mL | |
| 50 mM | 0.0655 mL | 0.3274 mL | 0.6547 mL | 1.6368 mL | |
| 60 mM | 0.0546 mL | 0.2728 mL | 0.5456 mL | 1.3640 mL | |
| 80 mM | 0.0409 mL | 0.2046 mL | 0.4092 mL | 1.0230 mL |
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