1. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  2. Reactive Oxygen Species
  3. Zedoarondiol

Zedoarondiol, a sesquiterpene lactone compound, with antioxidant and anti-inflammatory activity. Zedoarondiol can be used for atherosclerosis research.

For research use only. We do not sell to patients.

Zedoarondiol Chemical Structure

Zedoarondiol Chemical Structure

CAS No. : 98644-24-7

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Based on 1 publication(s) in Google Scholar

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Description

Zedoarondiol, a sesquiterpene lactone compound, with antioxidant and anti-inflammatory activity. Zedoarondiol can be used for atherosclerosis research[1][2].

In Vitro

Zedoarondiol (5-20 μg/mL) attenuates HUVECs injury, up-regulated SOD activity, suppressed formation of MDA and ROS, and secretion and protein expression of IL-1β, TNF-α, and MCP-1 in injured HUVECs induced by oxidized low-density lipoprotein (ox-LDL)[1].
Zedoarondiol induces nuclear Nrf2 translocation from cytoplasm into nucleus and up-regulated expression of HO-1, NQO1, and Nrf2 in nucleus[1].
Zedoarondiol suppresses PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation and DNA synthesis, and induces cell cycle arrest in G0/G1 phase. In addition, Zedoarondiol activates AMPK and ACC, inhibited the phosphorylation of mTOR and p70S6K, increases the expression of p53 and p21, and decreases the expression of CDK2 and cyclin E[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

252.35

Formula

C15H24O3

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C[C@@]1([C@]2([H])[C@](CC1)([H])[C@@](O)(CC(/C(C2)=C(C)/C)=O)C)O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Zedoarondiol
Cat. No.:
HY-122915
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