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  3. Zedoarondiol

Zedoarondiol 

Cat. No.: HY-122915
Handling Instructions

Zedoarondiol, a sesquiterpene lactone compound, with antioxidant and anti-inflammatory activity. Zedoarondiol can be used for atherosclerosis research.

For research use only. We do not sell to patients.

Zedoarondiol Chemical Structure

Zedoarondiol Chemical Structure

CAS No. : 98644-24-7

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Description

Zedoarondiol, a sesquiterpene lactone compound, with antioxidant and anti-inflammatory activity. Zedoarondiol can be used for atherosclerosis research[1][2].

In Vitro

Zedoarondiol (5-20 μg/mL) attenuates HUVECs injury, up-regulated SOD activity, suppressed formation of MDA and ROS, and secretion and protein expression of IL-1β, TNF-α, and MCP-1 in injured HUVECs induced by oxidized low-density lipoprotein (ox-LDL)[1].
Zedoarondiol induces nuclear Nrf2 translocation from cytoplasm into nucleus and up-regulated expression of HO-1, NQO1, and Nrf2 in nucleus[1].
Zedoarondiol suppresses PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation and DNA synthesis, and induces cell cycle arrest in G0/G1 phase. In addition, Zedoarondiol activates AMPK and ACC, inhibited the phosphorylation of mTOR and p70S6K, increases the expression of p53 and p21, and decreases the expression of CDK2 and cyclin E[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

252.35

Formula

C15H24O3

CAS No.
SMILES

C[[email protected]@]1([[email protected]]2([H])[[email protected]](CC1)([H])[[email protected]@](O)(CC(/C(C2)=C(C)/C)=O)C)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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