2. GPCR/G Protein
  3. P2Y Receptor
  4. PPTN hydrochloride

PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity.

For research use only. We do not sell to patients.

PPTN hydrochloride Chemical Structure

PPTN hydrochloride Chemical Structure

CAS No. : 1992047-65-0

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10 mg USD 200 In-stock
25 mg USD 390 In-stock
50 mg USD 600 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of PPTN hydrochloride:

PPTN hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE PPTN hydrochloride

WB
IF

    PPTN hydrochloride purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2022 Nov 30;114:109507.  [Abstract]

    HQL6 or PPTN significantly decreases the expressions of NLRP3, ASC and caspase-1 p20 in synovial tissue of rats.

    PPTN hydrochloride purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2022 Nov 30;114:109507.  [Abstract]

    HQL6 or PPTN significantly decreases the colocalization of NLRP3 and ASC in synovial tissues of rats. NLRP3 protein, ASC protein and nucleus are marked with Alexa Fluor 488 (Green), Alexa Fluor 647 (Red) and DAPI (Blue), respectively.

    • Biological Activity

    • Purity & Documentation

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    • Customer Review

    Description

    PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity[1].

    IC50 & Target

    KB: 434 pM (P2Y14 receptor)[1]
    In Vitro

    PPTN exhibits strong selectivity for the P2Y14-R over the other seven nucleotide-activated P2Y receptors. 1 μM PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors[1].
    PPTN inhibits UDP-glucose-promoted chemotaxis in differentiated HL-60 human promyelocytic leukemia cells with IC50s of ~1 nM in the presence of 10 μM UDP-glucose and ~4 nM in the presence of 100 μM[1].
    PPTN (10 µM) significantly decreases the ratios of p-ERK1/2 to ERK1/2 and p-p38 to p38[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    PPTN hydrochloride Related Antibodies
    Molecular Weight

    511.96

    Formula

    C29H25ClF3NO2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    FC(F)(C1=CC=C(C2=CC=C3C(C4=CC=C(C=C4)C5CCNCC5)=CC(C(O)=O)=CC3=C2)C=C1)F.Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 250 mg/mL (488.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9533 mL 9.7664 mL 19.5328 mL
    5 mM 0.3907 mL 1.9533 mL 3.9066 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.89%

    COA (250 KB) HNMR (291 KB) LCMS (270 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.9533 mL 9.7664 mL 19.5328 mL 48.8319 mL
    5 mM 0.3907 mL 1.9533 mL 3.9066 mL 9.7664 mL
    10 mM 0.1953 mL 0.9766 mL 1.9533 mL 4.8832 mL
    15 mM 0.1302 mL 0.6511 mL 1.3022 mL 3.2555 mL
    20 mM 0.0977 mL 0.4883 mL 0.9766 mL 2.4416 mL
    25 mM 0.0781 mL 0.3907 mL 0.7813 mL 1.9533 mL
    30 mM 0.0651 mL 0.3255 mL 0.6511 mL 1.6277 mL
    40 mM 0.0488 mL 0.2442 mL 0.4883 mL 1.2208 mL
    50 mM 0.0391 mL 0.1953 mL 0.3907 mL 0.9766 mL
    60 mM 0.0326 mL 0.1628 mL 0.3255 mL 0.8139 mL
    80 mM 0.0244 mL 0.1221 mL 0.2442 mL 0.6104 mL
    100 mM 0.0195 mL 0.0977 mL 0.1953 mL 0.4883 mL
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    PPTN hydrochloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    PPTN1992047-65-0P2Y ReceptorP2Y14Anti-inflammatoryimmunep-ERK1/2ERK1/2p-p38p38Inhibitorinhibitorinhibit

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