1. GPCR/G Protein
  2. P2Y Receptor
  3. PPTN hydrochloride

PPTN hydrochloride 

Cat. No.: HY-110322
Handling Instructions

PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity.

For research use only. We do not sell to patients.

PPTN hydrochloride Chemical Structure

PPTN hydrochloride Chemical Structure

CAS No. : 1992047-65-0

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Description

PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity[1].

IC50 & Target

KB: 434 pM (P2Y14 receptor)[1]

In Vitro

PPTN exhibits strong selectivity for the P2Y14-R over the other seven nucleotide-activated P2Y receptors. 1 μM PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors[1].
PPTN inhibits UDP-glucose-promoted chemotaxis in differentiated HL-60 human promyelocytic leukemia cells with IC50s of ~1 nM in the presence of 10 μM UDP-glucose and ~4 nM in the presence of 100 μM[1].
PPTN (10 µM) significantly decreases the ratios of p-ERK1/2 to ERK1/2 and p-p38 to p38[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

511.96

Formula

C₂₉H₂₅ClF₃NO₂

CAS No.
SMILES

FC(F)(C1=CC=C(C2=CC=C3C(C4=CC=C(C=C4)C5CCNCC5)=CC(C(O)=O)=CC3=C2)C=C1)F.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PPTNP2Y ReceptorP2Y14Anti-inflammatoryimmunep-ERK1/2ERK1/2p-p38p38Inhibitorinhibitorinhibit

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PPTN hydrochloride
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HY-110322
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