1. Neuronal Signaling
  2. Beta-secretase
  3. Kushenol C

Kushenol C 

Cat. No.: HY-108966
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Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 µM.

For research use only. We do not sell to patients.

Kushenol C Chemical Structure

Kushenol C Chemical Structure

CAS No. : 99119-73-0

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Description

Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 µM[1][2].

In Vitro

Kushenol C dose-dependently suppresses the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. Kushenol C (50-100 µM;) significantly decreases the phosphorylation of both STAT1 molecules and STAT6 in a dose-dependent manner in LPS-stimulated RAW264.7 cells[1].
Kushenol C upregulates the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. In HaCaT cells, Kushenol C prevents DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevents reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells[1].
Kushenol C inhibits BChE and AChE with IC50s of 54.86 and 33.13 µM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

438.47

Formula

C₂₅H₂₆O₇

CAS No.

99119-73-0

SMILES

O=C1C(O)=C(C2=CC=C(O)C=C2O)OC3=C(C[[email protected]](C(C)=C)C/C=C(C)\C)C(O)=CC(O)=C13

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Kushenol CBeta-secretaseBACEβ-Secretaseanti-Inflammatoryanti-oxidativestressinflammatorymediatorInhibitorinhibitorinhibit

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Kushenol C
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HY-108966
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