Docosahexaenoyl serotonin
Based on 1 Customer Validation
Docosahexaenoyl serotonin (DHA-5-HT) is an endogenous n-3 fatty acid-serotonin conjugate. Docosahexaenoyl serotonin is an inhibitor of IL-17. Docosahexaenoyl serotonin has anti-inflammatory activity.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 283601-58-1
- Formula: C32H42N2O2
- Molecular Weight:486.69
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Docosahexaenoyl serotonin (100-500 nM, 24 h) inhibits IL-23-IL-17 signaling cascade in RAW264.7 macrophages stimulated by lipopolysaccharide (HY-D1056) with effective anti-inflammatory properties[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 283601-58-1
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Appearance Liquid
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Molecular Weight 486.69
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Formula C32H42N2O2
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Color Colorless to light yellow
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SMILES
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(NCCC1=CNC2=C1C=C(O)C=C2)=O
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Synonyms
DHA-5-HT
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (262 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Poland M, et al. Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages. Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):2020-2028. [Content Brief]
[2]. Wang Y, Balvers MGJ, Hendriks HFJ, Wilpshaar T, van Heek T, Witkamp RF, Meijerink J. Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862(9):823-831. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Docosahexaenoyl serotonin Related Classifications
HY-131397 Related Classifications
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